庆大霉素氟米龙滴眼液治疗白内障术后眼部炎症反应的有效性和安全性分析OA
The evaluate the efficacy and safety of Gentamicin and fluminolone eye drops in the treatment of ocular in-flammatory reaction after cataract surgery
目的 评价庆大霉素氟米龙滴眼液治疗白内障术后眼部炎症反应的有效性和安全性.方法 选取我院确诊为白内障并行超声乳化联合人工晶状体植入术患者,纳入年龄18～80周岁,按计划随访且临床资料及各项检查结果完整的患者51例,每例患者仅1只眼入选,其中试验组25例(25只眼),对照组26例(26只眼).试验组患者白内障术后应用复方庆大霉素氟米龙滴眼液,对照组患者术后应用单剂妥布霉素滴眼液和氟米龙滴眼液联合进行治疗,收集视力、眼压、球结膜充血和角膜水肿情况、眼部不良反应及房水细胞等炎症反应指标,并比较两组患者听力及患者血生化、凝血功能和尿常规等实验室检查.结果 试验组和对照组患者房水细胞、球结膜充血、角膜水肿、裸眼视力在各组中均无统计学意义.试验组和对照组最佳矫正视力在组间的差异(P组别=0.015)、时间点的差异(P时间<0.001)及组别和时点的交互作用(P交互=0.002)有统计学意义.试验组和对照组治疗前后眼压无明显变化.试验组和对照组患者中血生化检查、尿常规检查、听力及血中庆大霉素差异无统计学意义.结论 庆大霉素氟米龙抗炎预防感染的效果较好,可有效降低患者眼部的炎症反应,且不会显著增加患者的眼部不良反应,同时不会对患者的听力和肝肾功能造成明显损伤,符合临床对用药安全性的需求.
Objective To evaluate the efficacy and safety of Gentamicin and fluminolone eye drops in the treat-ment of ocular inflammatory reaction after cataract surgery.Methods A total of 51 patients aged 18～80 years who were diagnosed with cataracts and underwent phacoemulsification combined with intraocular lens implantation in our hospital were selected.They were followed up according to the plan and had complete clinical data and examination results.Only one eye of each patient was selected,including 25 patients in the experimental group and 26 in the control group.Collect visual acuity,intraocular pressure,conjunctival congestion and corneal edema,adverse eye reactions,inflammatory re-sponse indicators such as aqueous humor cells and anterior chamber scintillation,and compare the hearing of two groups of patients,as well as laboratory tests such as blood biochemistry,coagulation function,and urine routine.Results There were no statistically significant differences in the levels of aqueous humor cells,conjunctival congestion,corneal edema,and uncorrected visual acuity between the experimental and control groups,as well as the interaction between groups and time points.The difference in best corrected visual acuity between the experimental group and the control group(P group=0.015),the difference at different time points(P time<0.001),and the interaction between groups and time points(P in-teraction=0.002)were statistically significant.There was no statistically significant difference in the incidence of adverse effect between the experimental group and the control group,and there was no significant change in intraocular pressure before and after treatment in both groups.There was no statistically significant difference in blood biochemistry test re-sults,urine routine examination,hearing,and gentamicin levels between the experimental group and the control group pa-tients.Conclusions Gentamicin fluminolone has a good anti-inflammatory and infection prevention effect,which can ef-fectively reduce the inflammatory reaction of patients'eyes,and will not significantly increase the adverse effect in patients eyes.At the same time,it will not cause significant damage to patients'hearing and liver and kidney functions,which meets the clinical demand for drug safety.
张珑俐;柯屹峰;刘婷;刘守宽;李筱荣
300384 天津,天津医科大学眼科医院300384 天津,天津医科大学眼科医院300384 天津,天津医科大学眼科医院300384 天津,天津医科大学眼科医院300384 天津,天津医科大学眼科医院
庆大霉素氟米龙安全性治疗
GentamicinFluminoloneSafetyTherapy
《临床眼科杂志》 2026 (1)
6-11,6
天津市医学重点学科建设资助(TJYXZDXK-3-004A-2)
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