华蟾素片联合雷替曲塞治疗晚期胃癌的疗效及对血清DKK-1、COX2水平的影响OA

Objective To analyze the efficacy of Huachansu Tablets combined with raltitrexed in the treatment of advanced gastric cancer and its impact on serum levels of Dickkopf-related protein 1(DKK-1)and cyclooxygenase-2(COX2).Methods A total of 140 patients with advanced gastric cancer of exuberance of stomach heat syndrome admitted to the Second Affiliated Hospital of Air Force Medical University from January 2022 to March 2024 were selected as the studying subjects.The patients were divided into a control group(63 cases)and a study group(77 cases)based on the treatment regimens.The control group received raltitrexed monotherapy,while the study group received Huachansu Tablets combined with raltitrexed.Both groups were treated for 2 cycles,with 3 weeks per cycle.Changes in levels of helper T cells(Th17),regulatory T cells(Treg),serum DKK-1,COX2,and tumor markers including carcinoembryonic antigen(CEA),carbohydrate antigen(CA)199,CA242,and CA724 were observed before and after treatment.Clinical efficacy and the incidence of adverse reactions were compared between the two groups.Results(1)Regarding efficacy,after 2 cycles of treatment,the objective response rate(ORR)and disease control rate(DCR)in the study group were 46.75%(36/77)and 80.52%(62/77),respectively,significantly higher than 26.98%(17/63)and 55.56%(35/63)in the control group.Intergroup comparisons(by chi-square test)showed statistically significant differences(P＜0.05 or P＜0.01).(2)Regarding serum DKK-1 and COX2 levels,after treatment,serum levels of DKK-1 and COX2 were significantly decreased in both groups compared with those before treatment(P＜0.05),and the reduction in the study group was significantly greater than that in the control group(P＜0.05 or P＜0.01).(3)Regarding T-cell levels,after treatment,levels of Th17 and Treg in blood were significantly decreased in both groups compared with those before treatment(P＜0.05),and the reduction in the study group was significantly greater than that in the control group(P＜0.05 or P＜0.01).(4)Regarding tumor markers,after treatment,serum levels of CEA,CA199,CA724,and CA242 were significantly decreased in both groups compared with those before treatment(P＜0.05),and the reduction in the study group was significantly greater than that in the control group(P＜0.05 or P＜0.01).(5)Regarding adverse reactions,the incidences of gastrointestinal reactions,liver function impairment,leukopenia,and thrombocytopenia during treatment were significantly lower in the study group than in the control group,with statistically significant differences between groups(P＜0.05 or P＜0.01).Conclusion The combination of Huachansu Tablets and raltitrexed demonstrates significant efficacy in treating patients with advanced gastric cancer of exuberance of stomach heat syndrome.It effectively reduces tumor size,improves immune function,lowers serum levels of DKK-1,COX2,and tumor markers,and reduces the incidence of adverse reactions.