老年脑胶质瘤患者术后疲乏与免疫炎性标志物水平的相关性研究OA

Objective To explore the correlation between the severity of postoperative fatigue(POF)and the levels of im-mune and inflammatory markers in elderly patients with gliomas.Methods A total of 120 elderly patients with gliomas who underwent surgery from January 2022 to September 2024 were enrolled in this study.The severity of postoperative fatigue was assessed using the Cancer-related fatigue self-rating scale(CFS)on the 7th postoperative day.According to the evaluation results,45 patients were divid-ed into mild fatigue group(CFS≤3 points),50 into moderate fatigue group(CFS 4～6 points)and 25 into severe fatigue group(CFS≥7 points).Serum immune markers[CD4+/CD8+T cell ratio,natural killer cell(NK)activity]and inflammatory markers[C-reactive protein(CRP),interleukin-6(IL-6)]were detected on the 7th postoperative day.Pearson correlation analysis was used to compare the differences and correlations among the three groups.Results On the 7th day after surgery,statistically significant differences were observed among the three patient groups in terms of serum CD4+/CD8+T cell ratio,NK activity,CRP levels,and IL-6 levels(P<0.05).Compared with the mild fatigue group,the moderate fatigue group had lower CD4+/CD8+T cell ratio,NK activi-ty,and higher CRP and IL-6 levels,and the difference was statistically significant(P<0.05);compared with the mild fatigue group and the moderate fatigue group,the severe fatigue group had lower CD4+/CD8+T cell ratio,NK activity,and higher CRP and IL-6 levels,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that POF score was negatively correlated with CD4+/CD8+T cell ratio and NK activity(P<0.05)and positively correlated with CRP and IL-6 levels(P<0.05).Conclusion The severity of postoperative fatigue in elderly patients with gliomas is closely related to immune function and inflammato-ry markers.Patients with severe fatigue have significantly decreased immune function and increased inflammatory response.