2型糖尿病患者肌少性肥胖研究进展OA

In patients with type 2 diabetes mellitus(T2DM),the prevalence of sarcopenic obesity has been increasing an-nually,with its underlying mechanisms involving the interplay between insulin resistance and metabolic inflammation.Elucidating the pathophysiology of this metabolic syndrome is a core prerequisite for implementing precision medicine and delaying functional decline.To this end,this article systematically reviews the clinical definitions,diagnostic standards,and evaluation systems for sarcopenic obe-sity in elderly T2DM patients.It highlights the synergistic pathogenic mechanisms between the two conditions and further discusses the translational prospects for future personalized interventions and clinical pharmacological treatments.