当归多糖对运动性疲劳模型大鼠运动耐力的影响及抗氧化作用OA

Objective To observe the protective effects of Angelica sinensis polysaccharide(ASP)on fatigue caused by overload exercise and its impact on exercise endurance.Methods 50 male SD rats were randomly divi-ded into a blank group,model group,and low-dose(200mg/kg),medium-dose(400 mg/kg),and high-dose(800 mg/kg)ASP groups(n=10 per group).Except for the blank group,all other groups underwent 5％body weight-loaded swimming training for 15 consecutive days to establish weight-loaded swimming fatigue model.One hour before daily training,ASP groups received intragastric administration of corresponding doses,while the blank and model groups received an equal volume of physiological saline.After the experiment,levels of malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)in serum,heart,and liver tissues,as well as hepatic glycogen content in liver tissues,were measured.Results Compared with the model group,the high-dose ASP group showed significantly prolonged weighted swimming time(P＜0.01),and the low-,medium-,and high-dose ASP groups exhibited significantly extended exhaustive swimming time(P＜0.01).SOD levels increased significantly in the high-dose ASP group(heart),low-dose ASP group(liver),and serum of low-,medium-,and high-dose ASP groups(P＜0.05 or P＜0.01).GSH-Px levels increased markedly in the low-dose ASP group(liver)and serum of all ASP groups(P＜0.05 or P＜0.01).MDA levels decreased significantly in the heart of low-,medium-,and high-dose ASP groups,liver of medium-and high-dose ASP groups,and serum of low-and high-dose ASP groups(P＜0.05 or P＜0.01).Hepatic glycogen content rose significantly in the medium-and high-dose ASP groups(P＜0.01).Con-clusion ASP alleviates overload exercise-induced fatigue and enhances exercise endurance,demonstrating potential for developing health products for high-intensity exercise populations.