光诱导电子转移驱动的α-酮酯还原偶联高效构建碳-碳键OA

Catalytic reduction reactions using isopropanol(IPA)as a transfer hydrogenating agent are gaining significant attention due to the low cost and large-scale production of IPA.Traditional methods for carbon-carbon(C—C)bond construction often rely on expensive and scarce transition metal catalysts,raising concerns about sustainability and environmental impact.To address these challenges,we develop a bifunctional photocatalyst,phloroglucinol carbon quantum dot(PG-CQD).It facilitates catalytic transfer hydrogenation(CTH)with IPA as the hydrogen donor.PG-CQDs exhibit both dehydrogenation and reduction activities,enabling the formation of vicinal diols under mild conditions with visible light irradiation.We propose a CTH mechanism that has been successfully validated through experiments.The catalytic system demonstrates remarkable versatility,enabling the synthesis of various vicinal diols from diverse α-keto ester substrates with good or excellent yields.These findings offer a sustainable synthetic strategy that aligns with green chemistry principles and establish a promising pathway for the development of environmentally benign and energy-efficient organic transformations.