单纯性皮罗序列征下颌骨三维形态的稠密对应分析OA

Objective Isolated Pierre Robin sequence(Ⅰ-PRS)is caused by abnormal mandibular development,and traditional sparse landmark-based methods are insufficient to capture its complete 3D morphology.This study aimed to use dense correspondence-based 3D geometric morphometrics to precisely quantify mandibular features in Ⅰ-PRS and establish a morphological classification system.Methods This retrospective case-control study included CT data from 200 infants with Ⅰ-PRS and 31 normal infants.Mandibular models were generated through 3D reconstruction,and point-to-point registration was performed using dense correspondence analysis.Principal component analysis(PCA)was used to explore morphological variation within the Ⅰ-PRS group,followed by K-means clustering and canonical variate analysis(CVA)for subtype classification and validation.Results The Ⅰ-PRS mandible showed significant dysmorphology compared to normal controls,with the greatest variations found at the symphysis and mandibular angle.PCA and cluster analysis identified three stable morphotypes:Type I(short body,flat arch);Type Ⅱ(short ramus,V-shaped narrow arch,with posterior ramus rotation);and Type ⅡI(high-angle,flat arch).CVA confirmed the high statistical validity of this subtyping.Conclusion This study successfully quantified the morphological features of the Ⅰ-PRS mandible using dense correspondence analysis and,for the first time,identified and defined three objective morphological subtypes.This classification system provides an important morphological basis for understanding the clinical heterogeneity of Ⅰ-PRS and for guiding precision diagnosis and personalized surgical treatment.