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甲巯咪唑乳膏临床应用专家指导建议OA

Expert recommendations on the clinical application of thiamazole cream

中文摘要英文摘要

甲状腺功能亢进症是一种常见的内分泌代谢性疾病,抗甲状腺药物是最常应用的治疗方法.甲巯咪唑乳膏作为一种新型透皮给药制剂,可通过局部给药实现对甲状腺区域的靶向作用,在保证疗效的同时显著降低全身血药浓度,从而减少肝损伤、粒细胞缺乏等全身性不良反应的风险,为甲亢治疗提供了新的选择.为帮助临床医生规范、合理使用甲巯咪唑乳膏,相关领域专家基于现有临床研究与专家经验,共同制定了专家指导建议,旨在明确其作用机制、适应证、用法、用量与不良反应处理等,以提升治疗的安全性与有效性.

Hyperthyroidism is a common endocrine and metabolic disorder,and antithyroid drugs is the most frequently used treatment approaches.Thiamazole cream,as a novel transdermal delivery formulation,enables targeted application to the thyroid region,ensuring therapeutic efficacy while significantly reducing systemic drug exposure,thereby lowering the risk of systemic adverse reactions such as hepatotoxicity and agranulocytosis.It provides a new option for the management of hyperthyroidism.To assist clinicians in the standardized and rational use of thiamazole cream,experts in related fields have developed this guidance document based on existing clinical research and expert experience.It aims to clarify its mechanism of action,indications,dosage,adverse reaction management,with the goal of enhancing treatment safety and effectiveness.

《甲巯咪唑乳膏临床应用专家指导建议》专家组;单忠艳

医药卫生

甲巯咪唑乳膏透皮给药甲状腺功能亢进症专家指导建议

thiamazole creamtransdermal drug deliveryhyperthyroidismexpert recommendations

《中国实用内科杂志》 2026 (2)

113-120,8

国家自然科学基金(72374007)

10.19538/j.nk2026020106

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