终末期肝病继发深部真菌感染临床诊治进展OA
Progress in clinical diagnosis and treatment of deep fungal infections secondary to end-stage liver disease
终末期肝病(end stage liver disease,ESLD)患者因各种机制,包括免疫麻痹和免疫亢进而易发生感染,其中真菌感染诊断较难且短期病死率较高.文章就ESLD继发深部真菌感染的流行病学、临床表现、相关检查和药物治疗进展进行阐述,以期提高临床医生对ESLD继发深部真菌感染的早期预警和早期诊断能力,帮助其合理选择抗真菌治疗药物.
Patients with end-stage liver disease(ESLD)are susceptible to infections due to various mechanisms,including immune paralysis and immune imbalance.The diagnosis of fungal infections is difficult,and the short-term mortality rate is very high.This article reviews the epidemiology,clinical manifestations,related examinations and progress in pharmacotherapy of fungal infections secondary to ESLD,aiming to improve clinicians' ability in early warning and early diagnosis of ESLD-related secondary fungal infections and promote the rational selection of antifungal therapeutic drugs.
王冰瑶;郑建铭
复旦大学附属华山医院感染科,上海 200040复旦大学附属华山医院感染科,上海 200040
医药卫生
终末期肝病真菌感染诊断治疗
end-stage liver diseasefungal infectiondiagnosistreatment
《中国实用内科杂志》 2026 (2)
108-112,5
国家重点研发计划(2023YFC2308800,2023YFC2308802)
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