终末期肝病合并细菌、真菌感染的免疫失衡OA
Immune imbalance in bacterial and fungal infections in patients with end-stage liver disease
终末期肝病(end-stage of liver disease,ESLD)为慢性肝脏损伤进展的终末阶段,与感染互为因果.在ESLD合并感染的免疫病理机制中,免疫失衡占据核心地位,具体表现为典型的"双相免疫失衡":早期以免疫亢进伴全身炎症反应综合征(SIRS)为特征,后期则进入免疫麻痹状态.肠道菌群移位等因素可进一步加剧免疫紊乱,推动"免疫紊乱-感染-器官损伤"恶性循环的形成.
End-stage liver disease(ESLD)represents the terminal stage of chronic liver injury progression,and it has a mutually causal relationship with infection.In the immunopathological mechanism of ESLD complicated with infection,immune paralysis and immune imbalance occupy a core position,which is specifically manifested as the typical"biphasic immune imbalance":the early stage is characterized by immune hyperactivity accompanied by systemic inflammatory response syndrome(SIRS),while in the late stage it progresses to an immunoparalytic state.Such factors as intestinal bacterial translocation can further exacerbate immune disorders and promote the formation of a vicious cycle of"immune disorder-infection-organ injury".
刘静;赖秀汶;雷姿颖;余雪
中山大学附属第三医院感染性疾病专科,广东 广州 510630中山大学附属第三医院感染性疾病专科,广东 广州 510630中山大学附属第三医院感染性疾病专科,广东 广州 510630中山大学附属第三医院感染性疾病专科,广东 广州 510630
医药卫生
终末期肝病感染免疫失衡免疫亢进免疫麻痹
end-stage liver diseaseinfectionimmune imbalanceimmune hyperactivityimmune paralysis
《中国实用内科杂志》 2026 (2)
103-107,5
中山大学附属第三医院2023年度临床医学研究专项基金(远航计划)(YHJH202305)
评论