放射性口腔黏膜炎的疾病管理模式OA
Disease management model of radiation-induced oral mucositis
放射性口腔黏膜炎(radiation-induced oral mu-cositis,RIOM)是头颈部肿瘤放疗、放化疗中常见且可限制治疗连续性的毒性反应,表现为口腔黏膜红斑、糜烂或溃疡、显著疼痛,常并发营养不良和感染.文章基于现有RIOM相关国内外指南和我国团体标准,提出一体化全周期管理模式:放疗前进行系统口腔评估、风险分层和健康教育;围疗程阶段以规范化口腔卫生管理为核心,辅以适宜的局部或全身预防措施;治疗阶段根据分级严重程度,综合应用镇痛、抗感染、营养支持和促愈合干预,必要时优化放疗计划;放疗后结合定期随访、患者报告结局(pa-tient-reported outcome measures,PROMs)和质量改进(quality improvement,QI)指标,形成动态闭环.该模式旨在降低重度RIOM的发生率和治疗中断率,缩短愈合时间,并改善患者生活质量.
Radiation-induced oral mucositis(RIOM)is a common toxic reaction that may limit continuous treatment in head-and-neck radiotherapy and chemoradiotherapy.It typi-cally presents with oral mucosal erythema,erosions or ulcers,and severe pain,often accompanied by malnutrition and infec-tion.Based on current national and international guidelines and the Chinese group standards,this paper puts forward an integrated,full-cycle management model,including:systemat-ic oral evaluation,risk stratification,and health education be-fore radiotherapy;standardized oral hygiene management sup-ported by appropriate local or systemic prophylactic measures through the course of treatment;severity-based therapeutic strategies that combine analgesia,anti-infection,nutritional support,and pro-healing interventions during treatment,with radiotherapy plan optimized if necessary;regular follow-up combined with patient-reported outcome measures(PROMs)and quality improvement(QI)indicators to form a closed man-agement loop.This model is designed to reduce the incidence of severe RIOM and treatment interruptions,accelerate heal-ing,and improve patients' quality of life.
朱伟文;范媛
南京医科大学附属口腔医院黏膜病科,口腔疾病研究与防治国家及重点实验室培育单位(南京医科大学),江苏省口腔转化医学工程研究中心(南京医科大学),江苏南京 210029南京医科大学附属口腔医院黏膜病科,口腔疾病研究与防治国家及重点实验室培育单位(南京医科大学),江苏省口腔转化医学工程研究中心(南京医科大学),江苏南京 210029
医药卫生
放射性口腔黏膜炎风险评估临床分级临床质量改进
radiation-induced oral mucositisrisk assess-mentclinical gradingclinical quality improvement
《中国实用口腔科杂志》 2026 (1)
27-31,5
江苏省科技厅重点研发项目(社会发展)专项基金(BE2021723)江苏省卫健委面上项目(H2023149)
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