光动力疗法联合盐酸米诺环素治疗种植体周炎的短期疗效及对血清炎性因子的影响OA
The short-term efficacy of photodynamic therapy combined with minocycline hydrochloride in the treatment of peri-implantitis and its influence on serum inflammatory factors
目的:探究光动力疗法(photodynamic therapy,PDT)联合盐酸米诺环素治疗种植体周炎(peri-implanti-tis,PI)的短期疗效及对血清炎性因子的影响.方法:选取本院 116 例PI患者随机数字表法分为对照组和实验组(2023 年 8 月～2024 年 11 月),各 58 例.对照组给予盐酸米诺环素治疗,实验组在对照组处理基础上给予PDT治疗.比较两组的疗效、血清炎性因子、牙龈指数(gingival index,GI)、牙周探诊出血指数(sulcus bleeding index,SBI)、菌斑指数(plaque index,PLI)、探诊深度(probing depth,PD)以及不良反应情况.结果:实验组在治疗后显示出比对照组更优的总有效率(χ2=5.098,P<0.05).治疗后,实验组白细胞介素-2(interleukin-2,IL-2)、IL-6、IL-1β、GI、SBI、PLI、PD低于对照组(t=6.058、4.538、7.729、3.629、3.604、3.674、4.141,P<0.05).结论:PDT联合盐酸米诺环素治疗PI能下调促炎因子表达,减轻种植体周围炎症反应,安全性良好,疗效显著.
Objective:Investigating the short-term efficacy of photodynamic therapy(PDT)combined with minocy-cline hydrochloride in the treatment of peri-implantitis(PI)and its impact on serum inflammatory factors.Methods:Totally 116 patients with PI were stochastically classified into the control group and the experimental group(from August 2023 to No-vember 2024),each with 58 patients.The control group adopted minocycline hydrochloride,while the experimental group a-dopted PDT in addition to the control group.The efficacy,serum inflammatory factors,gingival index(GI),periodontal sulcus bleeding index(SBI),plaque index(PLI),probing depth(PD),and adverse reaction situation.Results:After therapy,the ex-perimental group had higher total effective rate than the control group(χ2=5.098,P<0.05).After therapy,the experimental group had lower interleukin-2(IL-2),IL-6,IL-1β,GI,SBI,PLI,and PD than the control group(t=6.058,4.538,7.729,3.629,3.604,3.674,4.141,P<0.05).Conclusion:PDT combined with minocycline hydrochloride in the treatment of PI can down-regulate the expression of pro-inflammatory factors and reduce the inflammatory response around the implant,with good safety and significant efficacy.
古林娟;董瑜;张波;张悦;伊远平;杨静
西安市第三医院口腔科 陕西 西安 710018西安市第三医院口腔科 陕西 西安 710018西安市第三医院口腔科 陕西 西安 710018西安市第三医院口腔科 陕西 西安 710018西安市第三医院口腔科 陕西 西安 710018西安市第三医院口腔科 陕西 西安 710018
医药卫生
光动力疗法盐酸米诺环素种植体周围炎炎性因子
Photodynamic therapyMinocycline hydrochloridePeri-implantitisInflammatory factor
《临床口腔医学杂志》 2026 (2)
95-98,4
西安市卫生健康委员会科技项目(J201902046)西安市第三医院科研项目(Y2023yxyj11)
评论