基于孟德尔随机化探究组织蛋白酶与急、慢性牙周炎的因果关联OA

Objective:To explore the clear causal association between 9 types of cathepsin(CTS)and acute periodontitis(AP)and chronic periodontitis(CP)using Mendelian randomization(MR).Methods:Genome-wide association studies(GWAS)data related to 9 CTSs and GWAS data of AP and CP populations were used for two-way MR analysis and multivariate MR analysis.The two-way causal relationship between the 9 CTSs and AP and CP was systematically explored by using inverse variance weighting(IVW)as the main method,and the independent causal effect CTS of the 9 CTSs on AP and CP were deter-mined by multivariate MR analysis.Results:In the forward MR analysis,the IVW results showed that there was a significant neg-ative correlation between CTSO and AP[OR(95%CI)=0.478(0.253-0.901),P=0.022].The results of reverse MR analysis showed that there was a significant negative correlation between AP and CTSF[OR(95%CI)=0.987(0.979-0.996),P=0.005].There was a significant positive correlation between CP and CTSG[OR(95%CI)=1.027(1.000-1.055),P=0.046]and CTSS[OR(95%CI)=1.035(1.002-1.069),P=0.037].The results of multivariate MR analysis showed that there was a negative corre-lation between CTSG and AP[OR(95%CI)=0.493(0.282-0.861),P=0.013].There was a positive correlation between CTSS and AP[OR(95%CI)=1.449(1.012-2.074),P=0.042].Conclusion:CTS plays a regulatory role in the development of AP and CP,which provides a new idea for the relationship between CTS and AP and CP,and provides new clues for its pre-vention and treatment.