Th1/Th2、Th17/Treg失衡与儿童激素耐药型肾病综合征的相关性分析OA

Objective:To investigate Helper T cells(Th)1/Th2,Th17/regulatory T cells(Treg).Association between Treg imbalance and steroid resistant nephrotic syndrome(SRNS)in children.Methods:A total of 142 children with primary ne-phrotic syndrome were recruited and were given glucocorticoid therapy for 4 weeks.The children were classified into steroid-sensitive nephrotic syndrome(SSNS)according to treatment response.SSNS 31 cases(SSNS group)and SRNS 111 cas-es(SRNS group).Another 53 healthy children were selected as control group.Th1/Th2 and Th17/Treg in peripheral blood were detected.The correlation factors affecting SRNS and the value of Th1/Th2 and Th17/Treg in diagnosing SRNS were analyzed.Results:The levels of Th2,Th17 and Th17/Treg in peripheral blood of SRNS and SSNS groups were higher than those of con-trol group(P<0.05),SRNS group was higher than that of SSNS group(P<0.05),and Th1,Treg and Th1/Th2 ratios of SRNS and SSNS groups were lower than those of control group(P<0.05).The SRNS group was lower than the SSNS group(P<0.05).Microscopic hematuria,urinary protein and Th17/Treg were risk factors for SRNS(P<0.05),and Th1/Th2 were pro-tective factors(P<0.05).Combined Th1/Th2 and Th17/Treg diagnosed that the area under the curve of SRNS was 0.831,which was higher than that of Th1/Th2 and Th17/Treg alone(P<0.05).Conclusion:The decrease of Th1/Th2 and the in-crease of Th17/Treg in peripheral blood of children with SRNS are related to the occurrence of SRNS,and are potential biomark-ers for the diagnose of SRNS.