MTHFS基因多态性及单倍型与老年高血压易感性的关联研究OA

Objective:To be a globally prevalent chronic disease,hypertension is prevalent in the elderly population.Although a large number of single nucleotide polymorphisms(SNPs)associated with hypertension have been identified,further exploration is needed.This study investigates the association between MTHFS gene polymorphisms and hypertension susceptibility in the el-derly.Methods:We recruited 583 hypertensive patients and 421 healthy controls.Five MTHFS SNPs(rs685487,rs622506,rs6495446,rs2562744,and rs2586179)were genotyped using the Agena MassARRAY platform.PLINK software was used for Logistic regression analysis to evaluate association between SNPs and hypertension risk.The forest plot of significant association results was generated using Sangerbox software.Haplotype analysis was performed using Haploview and SNPStats software.The multifactor dimensionality reduction method assessed SNP-SNP interactions.Results:This study found that the rs2562744 A al-lele was significantly linked to increased hypertension risk.Carriers of CA or AA genotypes of rs2562744 had a significantly in-creased risk of hypertension than CC genotypes.The CA genotype of rs2562744 was significantly associated with an increased risk of hypertension in individuals over 70 years old.In males,the rs2562744 also showed a significant association with increased hyper-tension risk.The AC haplotype,formed by rs685487 and rs622506,was significantly linked to hypertension risk.The interaction between rs2562744 and rs2586179 may be important for predicting hypertension risk.Conclusion:The MTHFS rs2562744 poly-morphism is associated with an increased risk of hypertension in the elderly.These findings provide new clues for exploring the po-tential role of the MTHFS gene in the pathogenesis of hypertension and may provide a reference for personalized prevention and treatment strategies for elderly hypertension in the future.