基于"伏邪"理论探讨类风湿关节炎的态靶辨治OA

Rheumatoid arthritis(RA)is an autoimmune inflammatory disease that can be categorized under the traditional Chinese medicine(TCM)concept of"Bi syndrome."It causes joint pain,bone destruction,and extrasynovial multisystem damage,posing severe threats to patients' health.Based on the disease's onset characteristics,we illustrate the theory of"latent pathogens"combined with the syndrome-target differentiation and treatment concept,divide the disease into four stages:emergence,expansion,latency,and chronicity.This approach aligns with the evolution of pathogenesis,identify the challenge of recurrent episodes and difficulty in achieving a cure,and provide new ideas for the holistic differentation and treatment of RA,forming a general principle of strengthening the vital qi,dispelling cold and dampness,clearing blood stasis and heat,and unblocking meridians for RA treatment.In terms of disease manifestations,five states of"deficiency,cold,dampness,heat,and stasis"are summarized.With Guizhi Shaoyao Zhimu Decoction as the main prescription targeting the disease,staging-based modification as the foundation,adjustments needed to be made according to the patient's most prominent state,and incorporation of target drugs aimed at symptoms,physicochemical indicator,and imaging targets.RA treatment system based on staged differentiation and targeted therapy is constructed to improve the clinical effecacy.