从孙络与微血管相关性探析虫类药在经皮冠状动脉介入术后心绞痛中的应用OA
Exploring the application of insect-based drugs in angina pectoris after percutaneous coronary intervention from the perspective of the correlation between Sun collaterals and microvessels
经皮冠状动脉介入(PCI)术后心绞痛为目前冠心病手术治疗后常见的临床综合征.中医学在改善患者心绞痛症状、减少发作频率、提高生活质量方面具备独特优势.中医孙络与现代医学微血管在解剖分布、生理功能及病理表现上具有高度一致性,共同构成气血渗灌的末端网络.从孙络与微血管的相关性出发,本团队认为"孙络不畅,心脉不通"为PCI术后心绞痛核心病机,具体表现为孙络失养,络脉虚而留滞,治以虫药温养,荣络脉而通滞;孙络瘀阻,血滞玄府不通,治以虫药逐瘀,通孙络而开阖;孙络寒凝,阳微阴浊痹阻,治以虫药通阳,散阴浊而蠲痹;孙络挛急,络虚风动作痛,治以虫药息风,缓挛急而止痛.通过中西医理论结合,为PCI术后心绞痛提供了"孙络—微血管"层面的病机新解及虫类药精准治疗方案,丰富了络病理论的临床应用,为改善患者预后提供了新思路.
Angina pectoris after percutaneous coronary intervention(PCI)is a common clinical syndrome following surgical treatment of coronary heart diseases.Traditional Chinese medicine(TCM)has unique advantages in improving angina symptoms,reducing attack frequency,and enhancing quality of life.TCM Sun collaterals and modern medical microvessels are highly consistent in anatomical distribution,physiological functions,and pathological manifestations,jointly forming the terminal network of qi and blood perfusion.Based on the correlation between Sun collaterals and microvessels,the core pathogenesis of post-PCI angina is considered"obstructed Sun collaterals and blocked heart meridians",with specific manifestations as follows:Sun collaterals deficiency with stagnation,treated by warming and nourishing with insect-based drugs to nourish collaterals and resolve stagnation;Sun collaterals blocked by blood stasis,with blood stagnation obstructing Xuanfu(skin pores or micro-orifices),treated by eliminating blood stasis with insect-based drugs to dredge Sun collaterals and regulate opening-closing;Sun collaterals of cold coagulation,Yang deficiency and Yin turbidity obstruction,treated by activating Yang with insect-based drugs to dissipate Yin turbidity and relieve obstruction;Sun collaterals spasm due to collateral deficiency and stirring of wind,causing pain,treated by calming wind with insect-based drugs to relieve spasm and pain.By integrating TCM and Western medicine theories,this study provides a new interpretation of pathogenesis at the"Sun collaterals-microvessels"level and a precise insect-based treatment for post-PCI angina,enriches the clinical application of collateral disease theory,and offers new ideas for improving patient prognosis.
王宇婷;宁博;王凯;陈红羽;何丽红;张智茹;雷雨轩;王文丽;赵明君
陕西中医药大学附属医院 咸阳 712000广州中医药大学第二临床医学院陕西中医药大学第一临床医学院陕西中医药大学第一临床医学院陕西中医药大学第一临床医学院陕西中医药大学第一临床医学院陕西中医药大学第一临床医学院陕西中医药大学第二附属医院陕西中医药大学附属医院 咸阳 712000||陕西中医药大学第一临床医学院
医药卫生
经皮冠状动脉介入术后心绞痛孙络微血管虫类药络病理论
angina pectoris after percutaneous coronary interventionSun collateralsmicrovesselsinsect-based drugscollateral disease theory
《北京中医药大学学报》 2026 (2)
149-156,8
国家重点研发计划(No.2018YFC1704204)陕西省重点研发计划-重点产业创新链(群)项目(No.2024SF-ZDCYL-03-21)陕西省名中医赵明君传承工作室建设项目(No.2019007)陕西省省级院士工作站建设项目-吴以岭院士工作站(No.陕组通字[2019]49号-30)陕西省教育厅重点科研计划项目(No.22JS005)咸阳市重点研发计划项目(No.L2023-ZDYF-SF-047)秦创原中医药产业创新聚集区项目(No.L2024-QCY-ZYYJJQ-X223) National Key R&D Program of China(No.2018YFC1704204)
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