肌肉能量技术联合核心稳定性训练治疗非特异性下腰痛的疗效观察及其对IL-1β、IL-6、TNF-α的影响OA

Objective:To investigate the efficacy of muscle energy technique(MET)combined with core stability training(CST)in the treatment of non-specific low back pain(NLBP),and to explore its impact on serum interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor-alpha(TNF-α).Methods:A total of 200 NLBP patients were randomly divided into a control group(receiving routine care),test group A(receiving MET treatment),test group B(receiving CST treatment),and test group C(receiving combined MET and CST treatment),with 50 cases in each group.After 4 weeks of continuous treatment,the Quebec Back Pain Disability Scale(QBPDS)score,pain status[Visual Analog Scale(VAS)score],modified Japanese Orthopedic Association Back Pain Quality of Life Scale(JOA)score,anxiety scale score[Hospital Anxiety and Depression Scale-Anxiety(HADS-A)],depression scale score[Hospital Anxiety and Depression Scale-Depression(HADS-D)],sleep quality score[Pittsburgh Sleep Quality Index(PSQI)],and serum inflammatory factors(IL-1β,IL-6,TNF-α)levels were compared among the four groups.Results:After treatment,the QBPDS,VAS,HADS-A,and PSQI scores of test groups A,B,and C were significantly lower than those before treatment,while the JOA scores were significantly higher(all P<0.05).Among them,the improvements in QBPDS,VAS,and JOA scores in test group C were more significant than those in test groups A and B(P<0.05).After treatment,the serum levels of IL-1β,IL-6,and TNF-α in test groups A,B,and C were significantly lower than those before treatment(all P<0.05),and the improvement in IL-6 level in test group C was more significant than that in test groups A and B(P<0.05).There was a weak negative correlation between serum IL-6 level and JOA score in NLBP patients before treatment(r=-0.313,P=0.027).Conclusion:MET,CST,and their combination are all effective in treating NLBP,which can improve patients'symptoms,relieve pain,and reduce serum inflammatory factor levels,with the combined treatment showing the best efficacy.Serum IL-6 level in NLBP patients is negatively correlated with JOA score.