Advances in nanotechnology-augmented T cell-based novel cancer immunotherapiesOA
Malignant tumors are a leading global cause of death,motivating advances in treatment strategies.Conventional immunotherapies,including checkpoint inhibitors,vaccines,and cytokine therapies are limited by low response rates,toxicity,or target sites.Novel immunotherapies harness the patient’s T cells through genetic or redirection strategies but also encounter tumor microenvironment(TME)suppression,inefficient antigen presentation,and T cell exhaustion.Nanotechnology offers tailored solutions.Nanocarriers deliver molecules that modulate the TME for improved T cell infiltration,immunomodulators to overcome local immunosuppression,and viral antigen tags to induce antigen presentation.This enables the redirection of specific T cells,creating a platform for universal"off-the-shelf"therapy.This review discusses the application of nanomaterials to augment chimeric antigen receptor T(CAR-T)cell efficacy,harness bystander T cell activity,and reinvigorate pre-existing immunity.Key strategies include immune synapse modulation,barrier penetration,reducing T cell exhaustion,and sustaining longterm efficacy.Challenges in scalability,safety,and patient variability remain,urging development of smart nanosystems,personalized vaccines,and combination therapies.Nanotechnology promises to overcome current immunotherapy limitations and redefine cancer treatment paradigms toward potent,broad-spectrum,and durable tumor eradication.
Xinling He;Jing Du;Lingzhuo Zeng;Fan Tong;Jiaqi Ma;Nan Zeng;Chuan Hu;Huile Gao;Jinming Zhang
Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,West China School of Pharmacy,Sichuan University,Chengdu 610041,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,School of Modern Chinese Medicine Industry,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,ChinaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,West China School of Pharmacy,Sichuan University,Chengdu 610041,ChinaChinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China
医药卫生
nanotechnologynovel cancer immunotherapybystander T cellspre-existing immunityin vivo chimeric antigen receptor(CAR)cells
《Nano Research》 2026 (2)
P.592-611,20
supported by the National Natural Science Foundation of China(Nos.82274112,82404547,and 82574846)the Xinglin Scholar Research Promotion Project of Chengdu University of TCM(No.BSZ2023043)Technical Development Special Project of Sichuan Province(No.2024YFHZ0360).
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