What we can learn from fish calcitonin and its receptor:evolutionary insights and medical potentialOA
Editor’s note This manuscript offers a significant conceptual advance by addressing the long-standing challenge of calcitonin tachyphylaxis through an innovative evolutionary framework.Rather than an incremental finding,it reframes the problem by proposing that insights can be drawn from a naturally superior system in fish.It effectively bridges distinct,high-impact fields-evolutionary biology,structural biology,and translational medicine-providing both the“why”and the“how”behind the mechanistic differences.Furthermore,it outlines clear,actionable research strategies,such as designing stableα-helical calcitonin analogs,developing RAMP-agnostic modulators,and using peptides to disrupt the RAMP-CTR interface,which are likely to inspire and direct future experimental and therapeutic efforts.Given its direct relevance to unresolved clinical issues in osteoporosis,Paget s disease,and hypercalcemia,the work is poised to attract immediate interest from clinical endocrinologists and bone biologists.Its integrative and hypothesis-generating nature makes it a key reference in review articles across GPCR biology,evolutionary medicine,and bone therapeutics.
Yu-ying Yang;Jian-min Liu
Department of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Endocrine and Metabolic Diseases,and Shanghai Clinical Center for Endocrine and Metabolic Diseases,Shanghai 200025,China Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Clinical Research Center for Metabolic Diseases,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Endocrine and Metabolic Diseases,and Shanghai Clinical Center for Endocrine and Metabolic Diseases,Shanghai 200025,China Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Clinical Research Center for Metabolic Diseases,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
医药卫生
receptorcalcitoninevolutionary biologycalcitonin tachyphylaxisstructural biologyfishtranslational medicineosteoporosis
《LabMed Discovery》 2025 (4)
P.48-50,3
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