Biological properties and clinical applications of ceftobiprole:Current status and perspective reviewOA
Ceftobiprole,a novel fifth-generation cephalosporin,has gained significant attention as an anti-infective therapy because of its broad-spectrum activity against gram-positive and gram-negative bacteria,as well as its effectiveness against drug-resistant strains.This review provides a comprehensive overview of the chemical structure,mechanism of action,antibacterial spectrum,and pharmacokinetic/pharmacodynamic(PK/PD)characteristics of ceftobiprole,with a focus on its clinical efficacy and safety.We also explore its potential applications in treating infections such as skin and soft tissue infections,respiratory infections,and bloodstream infections and evaluate its effectiveness against drug-resistant pathogens.By summarizing current research and clinical practices,we aim to offer insights into optimizing clinical use and advancing antimicrobial agent development.
Shuai Zu;Ming-hui Wen;Yu-ying Lin;Lei Zheng;Xiu-mei Hu
Department of Laboratory Medicine,Guangdong Provincial Key Laboratory of Precision Medical Diagnostics,Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors,Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles,Nanfang Hospital,Southern Medical University,Guangzhou 501280,Guangdong,ChinaDepartment of Laboratory Medicine,Guangdong Provincial Key Laboratory of Precision Medical Diagnostics,Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors,Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles,Nanfang Hospital,Southern Medical University,Guangzhou 501280,Guangdong,ChinaDepartment of Laboratory Medicine,Guangdong Provincial Key Laboratory of Precision Medical Diagnostics,Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors,Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles,Nanfang Hospital,Southern Medical University,Guangzhou 501280,Guangdong,ChinaDepartment of Laboratory Medicine,Guangdong Provincial Key Laboratory of Precision Medical Diagnostics,Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors,Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles,Nanfang Hospital,Southern Medical University,Guangzhou 501280,Guangdong,China Guangdong Provincial Clinical Research Center for Laboratory Medicine,Guangzhou 510280,Guangdong,China State Key Laboratory of Multiorgan Injury Prevention and Treatment,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong,ChinaDepartment of Laboratory Medicine,Guangdong Provincial Key Laboratory of Precision Medical Diagnostics,Guangdong Engineering and Technology Research Center for Rapid Diagnostic Biosensors,Guangdong Provincial Key Laboratory of Single-cell and Extracellular Vesicles,Nanfang Hospital,Southern Medical University,Guangzhou 501280,Guangdong,China Guangdong Provincial Clinical Research Center for Laboratory Medicine,Guangzhou 510280,Guangdong,China
医药卫生
CeftobiproleBroad-spectrum antibacterial activityResistance mechanismAnti-infective therapyCommunity-acquired pneumonia(CAP)Penicillin-binding protein(PBP)Bloodstream infection(BSI)Pulmonary infectionCerebrospinal fluid(CSF)
《LabMed Discovery》 2025 (3)
P.22-29,8
supported by funding from the Noncommunicable Chronic Diseases-National Science and Technology Major Project(grant number:2024ZD0529005)National Natural Science Foundation of China(No.82230080)Guangdong Provincial Clinical Research Center for Laboratory Medicine(No.2023B110008)Clinical Research Project of Nanfang Hospital,Southern Medical University(No.2023CR015).
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