Unlocking immune responses via mitophagy genes: A dual-pronged strategy against hematologic tumorsOA

Mitophagy plays a complex role in cancer biology,particularly in hematologic malignancies.It can promote tumor survival and drug resistance by removing damaged mitochondria and reducing mitochondrial reactive oxygen species(ROs)or conversely inhibit tumor growth by diminishing cellular energy production.In hema-tologic cancers,mitophagy has dual regulatory effects:moderate mitophagy facilitates the removal of dysfunctional mitochondria and helps regulate ROs levels,supporting tumor cell survival;however,excessive mitophagy leads to a loss of mitochondrial integrity and induces cancer cell death.Given these contrasting ef-fects,therapeutic strategies must be carefully tailored to the specific biological context-either promoting or inhibiting mitophagy depending on the tumor type.In leukemia,lymphoma,and multiple myeloma,studies have demonstrated that modulating mitophagy can enhance therapeutic outcomes.Additionally,mitophagy has been shown to influence immune activation,a process critical for effective cancer treatment.This review synthesizes recent advances in our understanding of mitophagy pathways in hematologic tumors and highlights their role in regulating immune cell function,offering insights into their therapeutic potential.