The study on the effects of Paeoniae Radix Rubra-Angelicae Sinensis Radix before and after compatibility on energy metabolism in cold and heat syndrome model ratsOA
Background:Disorders of metabolism can affect the food intake,weight changes,and behavioral alterations of the body.Metabolic disorders are usually accompanied by the occurrence of diseases.We aimed to study the effects of the compatibility of Paeoniae Radix Rubra(PRR)and Angelicae Sinensis Radix(ASR)on the metabolic level of rats,and observe the changes in body weight and behavior.Discover the mechanism of preventing the occurrence of diseases by using PRR and ASR.Methods:Two animal models were induced by levothyroxine and low-temperature stimulation,followed by 21 days of edible traditional Chinese medicine administration.The changes in the rats’water intake,food intake,body temperature,and thermotactic behavior were recorded.Results:The results showed that PRR could cause an increase in the body weight of rats,a decrease in body temperature,and a stronger preference for warm environments.PRR inhibited thyroid function,the excitability of the nervous system,and energy metabolism.PRR upregulated the expressions of mTOR and TRPM8 while downregulating the expressions of AMPK and TRPV1.Conclusion:Our research findings suggest that the cold-natured PRR can inhibit the material and energy metabolism of the body and lower the body temperature,increasing the thermophilic behavior of rats.In contrast,ASR exhibited an antagonistic effect against PRR.
Shi-Hao Zhang;Jing Sun;Xiao-Fei Zhang;Fei Luan;Dong-Yan Guo;Ying Wang;Jun-Bo Zou;Bing-Tao Zhai;Jiang-Xue Cheng
Key Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaInfection Department,Xi’an Daxing Hospital,Xi’an 710003,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,ChinaKey Laboratory of Basic and New Drug Research in Chinese Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,China
医药卫生
Paeoniae Radix RubraAngelicae Sinensis Radixthermotropic behaviormaterial metabolismenergy metabolism
《Traditional Medicine Research》 2026 (5)
P.27-39,13
the preparation of this manuscript.This study was supported by the General Projects-Youth project(2022JQ-817)the Shaanxi University of Traditional Chinese Medicine Shaanxi Provincial Key Laboratory of Basic and New Drug Research Open Project(KF202303)the Research on process optimization and quality standard enhancement of five large varieties,including Four Seasons Antiviral Combination(2024CY-JJQ-36)the Shaanxi provincial science and technology department project(2025JC-YBMS-1033).
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