SnRK1 and TOR:central regulators of autophagy in plant energy stress responsesOA
Plants harness light through photosynthesis to produce chemical energy,a cornerstone of life on Earth.However,environmental challenges,such as insufficient light,nutrient deficiencies,and abiotic stresses,often disrupt energy availability,compelling plants to activate autophagy.This process degrades superfluous or damaged cellular components to recycle building blocks for vital functions.Like animals and yeast,plants employ conserved energy-sensing pathways,notably the antagonistic SNF1-related kinase 1(SnRK1;homologous to AMP-activated protein kinase in animals)and target of rapamycin(TOR)signaling cascades.Plants have also evolved unique strategies to initiate autophagy when faced with energy stress.Recent studies have elucidated plant-specific mechanisms,including the pivotal role of FCS-like zinc finger proteins in integrating stress and metabolic signals to modulate SnRK1 and TOR activity.This review synthesizes the current understanding of autophagy regulation in plants under energy stress,emphasizing how SnRK1 and TOR orchestrate cellular homeostasis.It also examines organelle-phagy-chlorophagy,mitophagy,and lipophagy-in sustaining energy balance during stress.Amid intensifying climate challenges,including drought,nutrient scarcity,and erratic weather,elucidating these mechanisms is critical for engineering crops with enhanced resilience and productivity,thereby addressing global food security challenges.Furthermore,as autophagy is conserved across eukaryotes,plant research offers insight into universal cellular processes,potentially informing applications related to human health.This review also consolidates recent advances and proposes future research to deepen our understanding of energy signaling and autophagy in plants.
Lei Feng;Xibao Li;Xuan-Ang Zheng;Zhao Zheng;Qing-Ren Liu;Chuanliang Liu;Qian-Lin Zhu;Wenjin Shen;Chao Yang;Hongbo Li;Xiaorong Wan;Yixiong Zheng;Jun Zhou;Caiji Gao
Guangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Applied Botany,South China Botanical Garden,Chinese Academy of Sciences,Guangzhou 510650,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangzhou Key Laboratory for Research and Development of Crop Germplasm Resources,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,ChinaGuangzhou Key Laboratory for Research and Development of Crop Germplasm Resources,Zhongkai University of Agriculture and Engineering,Guangzhou 510225,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,ChinaGuangdong Provincial Key Laboratory of Biotechnology for Plant Development,School of Life Sciences,MOE Key Laboratory&Guangdong Provincial Key Laboratory of Laser Life Science,and College of Biophotonics,South China Normal University,Guangzhou 510631,China
农业科技
Arabidopsis thalianaAutophagyEnergy stressFLZSnRK1TOR
《aBIOTECH》 2025 (4)
P.663-679,17
supported by the National Natural Science Foundation of China(32470353)Natural Science Foundation of Guangdong Province(2025A1515012500)China Postdoctoral Science Foundation(2023M741234)direct grants from South China Normal University(23KJ04)to LFthe National Natural Science Foundation of China(32270291,32470797)the Open Competition Program of Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2022SDZG05)the Guangdong Province Rural Revitalization Strategy Special Funding for Seed Industry Vitalization to CGand the National Natural Science Foundation of China(32071737)grants from the Department of Science and Technology of Guangdong Province(2023B0202010025)the Department of Education of Guangdong Province(2020ZDZX1013)to XRW.
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