Advances in smart hybrid scaffolds: A strategic approach for regenerative clinical applicationsOA
The emergence of innovative 3D-printed hybrid scaffolds is transforming the landscape of tissue engineering by effectively addressing various regenerative clinical challenges.These scaffolds,which combine the advantageous properties of metals,polymers,and ceramics,surpass the limitations associated with single-material constructs.This review provides a comprehensive analysis of the applications of hybrid scaffolds in cardiology,orthopedics,and neural tissue regeneration,highlighting their role in advancing biomimetics,accelerating wound healing,enabling targeted drug delivery,and facilitating tumor therapy.Critical factors such as biomechanical compatibility,bioactivity,degradation rates,and mechanical integrity are critically evaluated following scaffold integration into host tissues.Additionally,nano-topographical features are explored to assess scaffold performance and cellular interactions.Key architectural parameters such as porosity,pore size,and interconnectivity are analyzed for their biological implications in physiological conditions.Furthermore,the investigation extends to smart scaffolds that incorporate stimuli-responsive mechanisms through 4D printing and shape memory polymers,which mimic the complex and dynamic properties of living tissues in response to various stimuli.The review concludes by highlighting the significance of integrating stimuli-responsive characteristics as a fourth dimension in hybrid scaffolds,thereby enhancing their potential for advanced clinical applications.
Ahsan Riaz Khan;Amol D.Gholap;Navdeep Singh Grewal;Zhang Jun;Mohammad Khalid;Hai-Jun Zhang
Department of Interventional and Vascular Surgery,Shanghai Tenth People''s Hospital,Tongji University School of Medicine,Shanghai 200072,China National United Engineering Laboratory for Biomedical Material Modification,Branden Industrial Park,Qihe Economic&Development Zone,Dezhou City,Shandong 251100,ChinaDepartment of Pharmaceutics,St.John Institute of Pharmacy and Research,Palghar,401404,Maharashtra,IndiaUniversity of South Bohemia,Branisovska 1760,37005 Ceske Budejovice,Czech Republic Department of Mechanical Engineering,Guru Kashi University,Talwandi Sabo 151302,IndiaResearch Center for Translational Medicine,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200092,ChinaMaterials and Manufacturing Research Group,James Watt School of Engineering,University of Glasgow,Glasgow G128QQ,UK Sunway Centre for Electrochemical Energy and Sustainable Technology(SCEEST),Faculty of Engineering and Technology,Sunway University,No.5,Jalan Universiti,Bandar Sunway,47500 Selangor Darul Ehsan,Malaysia Centre for Research Impact&Outcome,Chitkara University Institute of Engineering and Technology,Chitkara University,Rajpura,140401,Punjab,IndiaDepartment of Interventional and Vascular Surgery,Shanghai Tenth People''s Hospital,Tongji University School of Medicine,Shanghai 200072,China National United Engineering Laboratory for Biomedical Material Modification,Branden Industrial Park,Qihe Economic&Development Zone,Dezhou City,Shandong 251100,China
医药卫生
Hybrid scaffoldsTissue engineeringRegenerative medicineSmart materialsAdditive manufacturing
《Engineered Regeneration》 2025 (1)
P.85-110,26
Study of smart biodegradable zinc-alloyed stents for the repair of vessels and steady state remodeling,National Nature Project Grant Number:82,270,535.
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