Mapping the trajectory of organoid research:Insights into complex models and advanced technologiesOA
In recent years,organoid technology has become a pivotal advancement in stem cell research,offering an unprecedented experimental platform that mimics the morphology and function of human organs,pushing modern life sciences to the forefront.This technology has successfully developed complex three-dimensional(3D)structures derived from human pluripotent or adult stem cells,closely resembling natural organs in tissue and function.Organoid models facilitate in-depth studies of organ development,disease progression,and drug interactions,effectively addressing ethical and practical limitations in traditional biomedical research.Despite its promising development,organoid technology faces challenges in practical applications,particularly in constructing complex organs like the brain,heart,and bone tissue.Therefore,we conducted a bibliometric analysis of 8051 publications on organoids from the Web of Science Core Collection(WoSCC)database(2000-2025).These studies were categorized into five clusters related to current situations and future application directions.Based on our bibliometric analysis,systematically summarize the development of organoid technologies,from laboratory to preclinical applications,exploration of complex organoids,and advanced technologies,while analyzing their limitations and prospects.This review will provide an objective perspective to identify current trends in organoid research and provide new insights into the future research and clinical applications of organoids by teasing out the past-present of organoid research.
Yiming Zhang;Lianyong Wang;Qingqian Zhao;Jinhao Gong;Ye Tian;Yang Liu;Shanfeng Chen;Xin Zhao;Qiang Yang;Yanhong Zhao
Tianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaDepartment of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaDepartment of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaDepartment of Applied Biology and Chemical Technology,The Hong Kong Polytechnic University,Hong Kong,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China Department of Spine Surgery,Tianjin Hospital,Tianjin University,Tianjin,ChinaTianjin Medical University Graduate School,Tianjin Medical University,Tianjin,China
医药卫生
Organoid researchBibliometric literature reviewPreclinical applicationComplex organoidsAdvanced technologies
《Engineered Regeneration》 2025 (1)
P.264-276,13
financial support from National Natural Science Foundation of China(U24A20670,82372419)Natural Science Foundation of Inner Mongolia Autonomous Region(2024QN08003).
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