黄芪治疗阿尔茨海默病的作用机制研究进展OA

Alzheimer's disease(AD)is a severe neurodegenerative disorder with complex pathogenesis and no definitive clinical cure.As a traditional Chinese medicine,Astragali Radix has demonstrated potential for multi-target intervention in AD prevention and treatment.Through systematic review,this study reveals that Astragali Radix and its active components(such as astragaloside IV and polysaccharides)exert effects not only by regulating Aβ homeostasis,inhibiting neuronal apoptosis,and protecting the blood-brain barrier but also by directly or indirectly suppressing Tau protein hyperphosphorylation,addressing the core pathology of AD.Mecha-nistically,Astragali Radix primarily exerts its multi-target synergistic therapeutic effects by modulating the apoptosis signaling path-way,the NF-κB/Nrf2-mediated neuroinflammation and oxidative stress core pathway,Tau-related pathways such as PPARγ/GSK-3β,and the MMPs system.This study systematically maps the molecular network of Astragali Radix in treating AD,providing important theoretical references for further research and clinical translation.However,it also highlights current gaps in understanding the direct mechanisms of Tau protein,exploration of flavonoid components,and clinical translation,which remain key future research directions.