从血证分期论治胃癌免疫治疗相关性皮疹病例报告OA
Treatment of Immunotherapy-Related Rash in Gastric Cancer Based on the Staging of Blood Syndrome Theory:A Case Report
在恶性肿瘤免疫治疗过程中,皮肤不良反应是常见并发症之一,以皮疹、瘙痒、白癜风等为主,其中皮疹可表现为红斑、鳞屑、渗血、溃疡及瘙痒等.孟金成教授认为"素体本虚,热毒灼血"是胃癌患者免疫治疗相关性皮疹的核心病机,并主张灵活运用《血证论》所载"止血、消瘀、宁血、补血"的原则进行分期论治.急性期治疗以止血消瘀、养血润燥为主,旨在迅速缓解皮损出血;缓解期出血减轻,治法转为补气宁血、健脾助运;恢复期则以补血调血、扶正固本为主,为患者后续治疗奠定良好基础.本文阐述孟金成教授治疗该病的具体应用,其核心思想是以血证论为纲,分期辨治;以扶正为要,固本培元,并结合一则临床验案以作佐证,彰显中医论治胃癌免疫治疗相关性皮疹的优势.
During cancer immunotherapy,cutaneous adverse reactions are common complications,primarily manifested as rash,pruritus,vitiligo,etc.Among these,rash may present as erythema,scaling,exudation,ulceration,and pruritus.Professor Meng Jincheng proposes that the core pathogenesis of immunotherapy-related rash in gastric cancer patients involves"deficiency of healthy qi with heat-toxin scorching the blood".He advocates for the flexible application of the principles of"stopping bleeding,eliminating blood stagnation,stabilizing blood,and tonifying blood"outlined in Blood Syndrome Theory for staged treatment.In the acute phase,treatment focuses on hemostasis,dispelling stasis,nourishing blood,and moistening dryness,aiming to promptly alleviate bleeding from skin lesions.During the remission phase,as bleeding diminishes,the therapeutic approach shifts to tonifying qi,stabilizing blood,strengthening spleen,and promoting transportation.In the recovery phase,the emphasis is on replenishing and regulating blood,as well as reinforcing healthy qi and consolidating the foundation,thereby establishing a solid basis for subsequent treatment.This paper elucidates Professor Meng Jincheng's specific application in treating this condition.The core strategy is guided by the blood syndrome theory,employing stage-based differentiation and treatment,while prioritizing the reinforcement of healthy qi to consolidate the root and nurture the primordial.A representative case is presented to demonstrate the advantages of traditional Chinese medicine approach in treating immunotherapy-related rash in gastric cancer.
刘俊桐;吴朝洋;莫炎华;钱薇;方灿途;孟金成
广州中医药大学第十临床医学院,广东 中山 528401||广州中医药大学附属中山中医院肿瘤科,广东 中山 528401广州中医药大学第十临床医学院,广东 中山 528401||广州中医药大学附属中山中医院肿瘤科,广东 中山 528401广州中医药大学第十临床医学院,广东 中山 528401||广州中医药大学附属中山中医院肿瘤科,广东 中山 528401广州中医药大学附属中山中医院肿瘤科,广东 中山 528401||中山市中医院肿瘤科,广东 中山 528401广州中医药大学第十临床医学院,广东 中山 528401||中山市中医院肿瘤科,广东 中山 528401广州中医药大学第十临床医学院,广东 中山 528401||中山市中医院肿瘤科,广东 中山 528401
医药卫生
胃癌免疫治疗相关性不良反应皮疹血证论分期论治
gastric cancerimmunotherapy-related adverse eventsrashblood syndrome theorystaged treatment
《中医肿瘤学杂志》 2026 (1)
98-104,7
广州中医药大学校院联合科技创新基金(编号:GZYZS2024U01).
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