牛膝温经汤治疗寒湿痹阻型膝骨关节炎的临床研究OA

Objective:To discuss the clinical efficacy of Niuxi Wenjing decoction in the treatment of knee osteoarthritis(KOA)with cold-dampness obstruction syndrome.Methods:Eighty patients with KOA and cold-dampness obstruction were randomly divided into observation group and control group with 40 cases in each group by using random number table method.The control group received oral celecoxib capsules,0.2 g each times,twice daily,whereas the observation group was given oral Niuxi Wenjing decoction,1 dose per day,taken warmly twice a day.Both treatments were given for 4 weeks.The changes in VAS scores,TCM symptom scores,WOMAC scores,musculoskeletal ultrasound assessments,and serum levels of IL-1β and TNF-α were observed before and after treatment.Results:No statistically significant differences were observed in any of observation indicators between the two groups before treatment(P>0.05).After treatment,sig-nificant decreases were found in all observation indicators within each group compared to their respective baseline levels(P<0.01).Compared with the control group,the observation group showed lower scores after treatment for both TCM syndrome assessment and WOMAC scores(P<0.01).Conclusion:Niuxi Wenjing decoction shows significant efficacy in the treatment of KOA with cold-dampness obstruction.The mechanism may be associated with the reduction of inflamma-tory factors(IL-1β,TNF-α).