Nrf2信号通路在肝脏缺血再灌注损伤中的保护机制及治疗前景的研究进展OA

Hepatic ischemia-reperfusion injury(HIRI)is a common and unavoidable complication following liver transplantation and hepatectomy.Its pathogenesis involves multiple pathophysiological processes,including oxidative stress,sterile inflammation,mitochondrial dysfunction,and apoptosis.Nuclear factor erythroid 2-related factor 2(Nrf2)is a key regulator of cellular antioxidant responses that maintains cellular redox balance by activating the expression of antioxidant factors such as heme oxygenase-1(HO-1),superoxide dismutase(SOD),and glutathione(GSH).Nrf2 also protects the liver by inhibiting the release of pro-inflammatory factors,regulating inflammatory signaling pathways,reducing inflammatory responses,and decreasing apoptosis.This review summarizes the mechanistic roles of Nrf2 in HIRI,recent advances in Nrf2 activators,and their prospects for clinical translation.Furthermore,it discusses the application potential of cutting-edge technologies such as artificial intelligence and organoid models in Nrf2-related research,aiming to provide a theoretical basis for the prevention and treatment of HIRI through targeting the Nrf2 signaling pathway.