复方苦参注射液治疗老年子宫内膜癌化疗后癌因性疲乏的疗效观察OA
Efficacy of Compound Kushen Injection in the Treatment of Cancer-Related Fatigue in Elderly Patients with Endometrial Cancer After Chemotherapy
目的:探讨复方苦参注射液对老年晚期子宫内膜癌化疗后患者癌因性疲乏及生活质量的影响.方法:选取 2022 年 1 月1 日至 2025 年 1 月 1 日华中科技大学同济医学院附属梨园医院肿瘤科、妇产科收治的老年晚期子宫内膜癌化疗后癌因性疲乏患者 98 例,按照治疗方法分为观察组(n=49)和对照组(n=49).对照组患者给予TP方案(紫杉醇+顺铂)或TC方案(紫杉醇+卡铂)化疗,观察组患者给予复方苦参注射液联合TP或TC方案化疗,两组患者均以 21 d为 1 个疗程,治疗 2 个疗程.比较两组患者治疗后的癌因性疲乏疗效、生活质量疗效和不良反应发生情况,以及治疗前后的血清C反应蛋白变化.结果:治疗后,观察组患者癌因性疲乏有效率为 51.02%(25/49),显著高于对照组的 14.29%(7/49);观察组患者生活质量改善率为 61.22%(30/49),显著高于对照组的 36.73%(18/49),差异均有统计学意义(P＜0.05).治疗后,观察组患者血清C反应蛋白水平较对照组明显降低,差异有统计学意义(P＜0.05).观察组患者的不良反应总发生率为 24.49%(12/49),明显低于对照组的 44.90%(22/49),差异有统计学意义(P＜0.05).结论:对于老年晚期子宫内膜癌患者,复方苦参注射液可改善其化疗后癌因性疲乏,减少不良反应发生,提高生活质量.
OBJECTIVE:To probe into the effects of compound Kushen injection on cancer-related fatigue and life quality in elderly patients with advanced endometrial cancer after chemotherapy.METHODS:A total of 98 elderly advanced endometrial cancer patients with cancer-related fatigue after chemotherapy admitted into Oncology Department,Obstetrics and Gynecology Department in Liyuan Hospital of Tongji Medical College of Huazhong University of Science and Technology from Jan.1st,2022 to Jan.1st,2025 were selected,patients were divided into observation group(49 cases)and control group(49 cases)according to different therapeutic methods.The control group was given TP regimen(paclitaxel+cisplatin)or TC regimen(paclitaxel+carboplatin)for chemotherapy,while the observation group received compound Kushen injection combined with TP or TC regimens for chemotherapy,both groups were treated for 2 courses,with each course for 21 d.The efficacy of cancer-related fatigue,life quality,the incidence of adverse drug reactions after treatment,and changes of serum C-reactive protein before and after treatment were compared between two groups.RESULTS:After treatment,the effective rate for cancer-related fatigue of observation group was 51.02%(25/49),significantly higher than 14.29%(7/49)of control group;the improvement rate of life quality of observation group was 61.22%(30/49),significantly higher than 36.73%(18/49)of control group,with statistically significant differences(P＜0.05).After treatment,the serum C-reactive protein level of observation group was significantly lower than that of control group,with statistically significant difference(P＜0.05).The incidence of adverse drug reactions of observation group was 24.49%(12/49),significantly lower than 44.90%(22/49)of control group,with statistically significant differences(P＜0.05).CONCLUSIONS:For elderly patients with advanced endometrial cancer,compound Kushen injection can effectively improve cancer-related fatigue after chemotherapy,reduce adverse drug reactions and improve life quality.
马瑞;余舒扬;马倩;申利
华中科技大学同济医学院附属梨园医院肿瘤科,武汉 430077华中科技大学同济医学院附属协和医院妇瘤科,武汉 430022华中科技大学同济医学院附属梨园医院肿瘤科,武汉 430077华中科技大学同济医学院附属梨园医院妇产科,武汉 430077
医药卫生
复方苦参注射液老年子宫内膜癌患者癌因性疲乏
Compound Kushen injectionElderly patientsPatients with endometrial cancerCancer-related fatigue
《中国医院用药评价与分析》 2026 (1)
60-63,4
湖北省卫生健康委科研项目(面上项目)(No.WJ2023M044)
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