治疗心系疾病的中药用药规律分析及药学监护探讨OA

OBJECTIVE:To analyze the medication rules of traditional Chinese medicine(TCM)in the treatment of cardiovascular diseases based on data mining technology,and to explore key pharmaceutical care points.METHODS:A database of TCM prescriptions for cardiovascular diseases was established.Data mining was performed on TCM prescriptions for inpatients from Jan.2022 to Jun.2023 by using the Cloud Platform for Medical Cases to analyze the medication patterns.The medication patterns in the treatment of cardiovascular diseases were analyzed,and the pharmacological care points for frequently used traditional Chinese medicines and those with high risks were summarized.RESULTS:A total of 3 741 inpatient TCM prescriptions were collected.The properties were mainly neutral,warm,and the flavors were predominantly sweet and bitter,the meridian tropism was primarily the lung and liver.Among the top 30 most frequently used Chinese medicines,23 exceeded the average dosage specified in the Pharmacopoeia of the People's Republic of China or the Beijing Specifications for the Processing of Traditional Chinese Medicinal Preparations.Association rule analysis revealed that the herb pairs with the highest support and co-occurrence were Carthami flos-Persicae semen and Poria cocos-Codonopsis radix.Cluster analysis revealed four core TCM combinations.(1)Poria cocos,Radix salviae,Codonopsis radix and Hedysarum Multijugum Maxim;(2)Radix bupleuri and Scutellariae radix;(3)Atractylodes macrocephala koidz,Pinelliae rhizoma praeparatum and Citrus reticulata;(4)Angelicae sinensis radix,Chuanxiong rhizoma,Achyranthis bidentatae radix,Paeoniae radix rubra,Persicae semen and Carthami flos.CONCLUSIONS:Strengthening the monitoring of the combined use of Chinese and Western medicines and adverse reactions during clinical medication for cardiovascular diseases can provide key pharmacovigilance monitoring points and reference basis for clinical Chinese medicine pharmacists in cardiology.