基于Hippo信号通路探讨中医药防治癌症的分子机制OA

The Hippo signaling pathway,as a highly conserved tumor suppressor pathway,is closely related to the occurrence and development of various malignant tumors due to the abnormal expression of its core components,mammalian STE20-like protein kinase 1/2(MST1/2),large tumor suppressor kinase 1/2(LATS1/2),and effector factor Yes-associated protein 1(YAP)/WW domain-containing transcription regulator 1(TAZ).This pathway plays a key regulatory role in pathological processes such as malignant proliferation,apoptosis,and drug resistance by regulating downstream target genes such as connective tissue growth factor(CTGF)and cysteine-rich angiogenic inducer 61(CYR61).Currently,it has been found through research that effective components of traditional Chinese medicine(TCM)and TCM formulas can exert anti-cancer effects by regulating the Hippo signaling pathway,but the specific targets and biochemical processes involved remain unknown.This article integrated the action targets and regulated biochemical processes of effective components of TCM targeting the Hippo signaling pathway in anti-tumor activities and discovered that flavonoids,terpenoids,glycosides,and other effective components of TCM and TCM formulas can regulate the Hippo signaling network,with the most significant mechanisms being the intervention of YAP/TAZ nuclear-cytoplasmic shuttling,restoration of the activity of Hippo core kinases,and blocking of crosstalk between pathways.Taking the Hippo pathway as the research object not only provides a new perspective for explaining the scientific connotation of TCM in anti-tumor activities but also lays a theoretical foundation for the development of new TCM drugs based on Hippo pathway-targeted therapy.