京津冀生物医药技术开发热点与趋势分析OA

Objective To investigate the research hotspots and development trends in biomedical technology in the Beijing-Tianjin-Hebei region.Methods Publicly available invention patent data related to biomedical technology in the Beijing-Tianjin-Hebei region from January 2015 to December 2024 were retrieved from the IncoPat patent database.The BERTopic model was used for clustering analysis,and its hierarchical clustering function was applied to integrate and summarize similar topics.Research hotspots were identified by combining dynamic trend changes.Results A total of 30 109 invention patent records in the field of biomedicine in the Beijing-Tianjin-Hebei region were obtained,including 22 454 from Beijing,4 699 from Tianjin,and 2 956 from Hebei.From 2015 to 2024,the number of authorized invention patents in biomedical technology in the region showed an overall trend of increasing first and then decreasing,peaking in 2022(5 005 patents).Beijing has always maintained a core leading position in terms of patent quantity,while Tianjin and Hebei,though with relatively fewer patents,have shown a steady growth trend,indicating the radiation effect of regional innovation.A total of 25 research topics were extracted and summarized into four research directions.Specifically,the research direction of frontier biopharmaceuticals and cell therapy focused on core themes such as microbial fermentation(1 732 patents),viral vaccines(1 345 patents),and stem cell therapy(1 330 patents);the research direction of molecular diagnostics and detection technologies focused on core themes such as tumor gene detection(2 776 patents),biochips(1 517 patents),and high-performance liquid chromatography detection(1 430 patents);the research direction of chemical drugs and novel formulations focused on core themes such as small-molecule compounds and derivatives(2 048 patents),oral and injection preparations(1 412 patents),and nano-drug formulations(1 245 patents);and the research direction of traditional Chinese medicine(TCM)and disease prevention and treatment focused on core themes such as extraction of TCM components(1 257 patents)and external TCM preparations(738 patents).Different research topics exhibited varying temporal trends.Topics such as microbial fermentation,viral vaccines,stem cell therapy,tumor gene detection,biochips,and nano-drug formulations showed rapid growth in recent years,becoming current research hotspots.Conclusion Biomedical technology in the Beijing-Tianjin-Hebei region are developing rapidly,with research hotspots concentrated in areas such as frontier biopharmaceuticals,molecular diagnostics,and novel formulations,demonstrating high development potential.The observed trend changes may be closely related to key technological breakthroughs,policy support,increased clinical demand,and accelerated industrialization.Further strengthening regional coordination and resource integration is necessary to enhance the overall innovation capability and industrial competitiveness of the Beijing-Tianjin-Hebei region.