定志丸的源流探析及现代应用OA
An Analysis of the Origins and Modern Applications of Dingzhi Pill
定志丸是治疗心气不定,五脏不足的经典方剂,为孙思邈治疗心气不足系列病症所设.目前发现,定志丸具有多种药理作用,包括抗近视发生与发展、改善学习记忆力、抗抑郁、改善睡眠、抗应激及增强免疫等,现代临床多用于治疗健忘、抑郁、失眠等神经内科疾病以及近视等眼科疾病.本文采用文献对比分析方法,考证定志丸的组成、剂量、炮制方法及其主治病症,发现历代关于定志丸的方剂组成和剂量有所变化,主治范围涵盖眼科疾病、心脑疾病、气血津液失调及肾系疾病等.现代应用主要集中在抑郁模型和各类学习障碍模型,但在近视模型方面的研究相对较少.本文可为定志丸的中医临床研究及复方制剂的开发提供参考.
Dingzhi Pill is a classic prescription for treating disorders caused by unstable heart Qi and insufficiency of the five organs.It was formulated by SUN Simiao for the treatment of heart Qi deficiency-related conditions.Dingzhi Pill has multiple pharmacological effects,including anti-myopia,improvement of learning and memory,antidepressant properties,sleep enhancement,stress resistance,and immune system modulation.In modern clinical practice,it is primarily used to treat neurological disorders such as memory loss,depression,and insomnia,as well as ocular diseases like myopia.This article employs a comparative literature analysis to investigate the composition,dosage,preparation methods,and therapeutic indications of Dingzhi Pill.The study reveals that the prescription's composition and dosage have evolved over time,with its therapeutic range extending to ophthalmic diseases,cardiovascular and cerebrovascular diseases,disorders of Qi,blood,body fluids,and kidney-related diseases.Modern applications are mainly focused on depression models and various learning impairment models,though research on its use in myopia models is relatively sparse.This article aims to provide a reference for future clinical studies of Dingzhi Pill in Traditional Chinese Medicine and the development of compound formulations.
张艳雪;吴凯;王逾俏;姚小磊
湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208湖南中医药大学第一附属医院,长沙 410007||湖南中医药大学,长沙 410208
医药卫生
定志丸源流古籍临床研究药理研究
Dingzhi Pilloriginsancient textsclinical researchpharma-cological research
《中国中医眼科杂志》 2026 (2)
196-200,5
1湖南省眼科疾病中医临床医学研究中心(2023SK4038) 2湖南省卫生健康高层次人才重大科研专项(20230493) 3湖南中医药大学"揭榜挂帅"项目(22JBZ029)
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