中国人内脏脂肪指数与中青年夜间高血压的相关性研究OA

Background The Chinese visceral adiposity index(CVAI)is a new obesity index that has been proven to be associated with prehypertension and hypertension.Still,there is a lack of research on the relationship between the CVAI and nocturnal hypertension(NH).Objective To investigate the correlation between CVAI and NH in young and middle-aged adults.Methods A total of 981 young and middle-aged patients with essential hypertension admitted to the Department of Hypertension of the Fifth Affiliated Hospital of Xinjiang Medical University were consecutively enrolled from February to September 2023,and the general data,biochemical indexes,and 24-hour ambulatory blood pressure monitoring results of the patients were collected and the CVAI was calculated,and the patients were divided into 95 cases of the non-nocturnal hypertension(NNH)group and 886 cases of the NH group according to the whether they were combined with NH or not.Differences in age,gender,and other indicators were compared between the two groups.Correlation analysis was performed using the Pearson or Spearman method.Multivariate Logistic regression was used to analyze the correlation between CVAI and NH in young and middle-aged people.Results Compared with the NNH group,the NH group had higher CVAI,24-hour average systolic and diastolic blood pressure,daytime average systolic and diastolic blood pressure,nocturnal average systolic and diastolic blood pressure,and maximum systolic and diastolic blood pressure,and the differences were statistically significant(all P<0.05).Pearson correlation analysis showed that CVAI was positively correlated with 24-hour average systolic and diastolic blood pressure,daytime average systolic and diastolic blood pressure,nocturnal average systolic and diastolic blood pressure,and maximum systolic and diastolic blood pressure(r=0.202,0.183,0.200,0.171,0.168,0.174,0.132,0.157,all P<0.05).Multivariate Logistic regression showed that high CVAI was an independent risk factor for NH in young and middle-aged adults after adjustment for relevant confounders(OR=1.009,95%CI=1.002-1.016,P=0.014).According to the CVAI quartiles,the patients were categorized into Q1 group(<103.524 3,n=245),Q2 group(103.524 3-129.714 0,n=246),Q3 group(129.714 0-156.270 4,n=245)and Q4 group(>156.270 4,n=245).The risk of developing nocturnal hypertension in the Q2 group,Q3 group and Q4 group was 1.779(OR=1.779,95%CI=1.002-3.157),2.023(OR=2.023,95%CI=1.061-3.858),and 3.053(OR=3.053,95%CI=1.383-6.737)times greater than that of the Q1 group.Subgroup analysis showed that the association between CVAI and NH was more significant in the overweight/obese(BMI≥24 kg/m2)population(P=0.021).Conclusion CVAI was associated with the risk of developing NH in young and middle-aged adults,and the association was more significant in the overweight/obese(BMI≥24 kg/m2)population,which was a risk factor for NH in this population.