微小RNA在结直肠癌上皮间质转化中的作用与研究进展OA

Colorectal cancer(CRC)is the third most common cancer globally,with an incidence rate ranked just behind lung cancer and breast cancer in women.Epithelial-mesenchymal transition(EMT)enhances the migratory and invasive abilities of tumor cells but is also closely associated with tumor recurrence and drug resistance.MicroRNAs(miRNAs)are a class of non-coding RNAs that regulate the EMT process through various mechanisms and pathways.Therefore,this review aims to summarize the roles and research progress of miRNAs in the regulation of EMT in CRC,providing new insights into the complex regulation of EMT and offering potential strategies for the prevention and treatment of CRC metastasis.