淋巴特异性解旋酶与肿瘤关系的研究进展OA
Research progress on the relationship between helicase,lymphoid specific and tumors
淋巴特异性解旋酶(HELLS)是一种定位于人类染色体10q23-q24区域的DNA解旋酶,在细胞周期进程与基因表达调控中占据着举足轻重的地位.近年来研究发现,HELLS与多种肿瘤的发生、发展密切相关,该基因可促进视网膜母细胞瘤、胶质母细胞瘤、肝细胞癌、胰腺癌和鼻咽癌等多种人类癌症的进展,并影响患者预后.HELLS表达水平的变化可作为潜在的诊断和预后标志物,为这些肿瘤的治疗和预防提供了一定的参考价值.本文就HELLS的分子结构与功能、HELLS与肿瘤的关系作一综述,揭示其作为肿瘤治疗靶点的潜力.
Helicase,lymphoid specific(HELLS),which are DNA helicases located in the 10q23-q24 region of human chromosomes,play a crucial role in cell cycle progression and gene expression regulation.Recent studies have demonstrated that HELLS is significantly associated with the onset and progression of various malignancies.This gene has been shown to facilitate the development of multiple human cancers,including retinoblastoma,glioblastoma,hepatocellular carcinoma,pancreatic carcinoma,and nasopharyngeal carcinoma,and affect the prognosis of patients.Alterations in its expression levels can serve as potential diagnostic and prognostic markers,providing valuable insights for the treatment and prevention of these tumors.This paper reviews the molecular structure and function of HELLS,and the relationship between HELLS and tumors,revealing their potential as therapeutic targets for tumors.
王身吾;李庄
大理大学第一附属医院甲乳外科,云南 大理 671000大理大学第一附属医院甲乳外科,云南 大理 671000
医药卫生
淋巴特异性解旋酶功能区域生物学功能肿瘤
helicase,lymphoid specificfunctional areabiological functiontumor
《局解手术学杂志》 2026 (2)
175-179,5
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