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天冬酰胺与肿瘤关系的研究进展OA

Research progress on the relationship between asparagine and tumors

中文摘要英文摘要

天冬酰胺(Asn)作为一种非必需氨基酸,在疾病的发展过程中扮演着举足轻重的角色,尤其在肿瘤细胞代谢调控和免疫调节方面发挥着关键作用.本文围绕肿瘤代谢及转移侵袭等核心生物学过程,从信号通路和分子机制方面,系统阐述了Asn参与上述病理进程的具体作用机制.同时,本文总结了近年来Asn在肿瘤治疗领域的研究进展及临床应用成果,并深入分析了其在后续研究与临床推广中可能面临的挑战,旨在为Asn在医学领域的进一步应用研究提供有力线索,并为相关领域的研究者提供有益的参考.

Asparagine(Asn),a non-essential amino acid,plays a pivotal role in the development of diseases,particularly in the metabolic regulation and immune modulation of tumor cells.This paper focuses on the core biological processes such as tumor metabolism and metastasis and invasion,and systematically elucidates the specific mechanisms of Asn participates in the above pathological processes from the perspectives of signaling pathways and molecular mechanisms.Meanwhile,this paper summarizes the research progress and clinical application achievements of Asn in the field of tumor therapy in recent years,and conducts an in-depth analysis of potential challenges in subsequent research and clinical promotion,aiming to provide valuable insights for further application studies of Asn in the medical field and offer useful references for researchers in related areas.

徐增强;姜萌昕;耿杨;朱佳浩;徐英江

滨州医学院第一临床医学院,山东 滨州 256600滨州医学院第一临床医学院,山东 滨州 256600滨州医学院第一临床医学院,山东 滨州 256600滨州医学院第一临床医学院,山东 滨州 256600滨州医学院附属医院介入血管外科,山东 滨州 256600

医药卫生

天冬酰胺肿瘤mTOR免疫代谢调控

asparaginetumormTORimmunemetabolic regulation

《局解手术学杂志》 2026 (2)

170-174,5

国家自然科学基金(82200981)山东省自然科学基金(ZR2022QH358)泰山学者工程专项经费资助(tsqn202312384)

10.11659/jjssx.04E025051

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