环化酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子通路在眼部疾病中作用的研究进展OA
Research progress on the role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in eye diseases
病原体感染和非致病性因素可触发免疫反应,导致眼部炎症.环化酸鸟苷-腺苷酸合成酶(cGAS)-干扰素基因刺激因子(STING)通路是最近发现的一种炎症信号通路,它将双链DNA识别为激活信号,以促进炎症反应或自身免疫反应的下游细胞因子的表达.越来越多的证据表明,cGAS-STING信号转导通路在介导眼部炎症和炎症相关疾病,包括干眼、角膜炎、葡萄膜炎、青光眼、糖尿病视网膜病变和年龄相关性黄斑变性等炎症反应中起关键作用.本文就cGAS-STING通路在眼部疾病中作用的研究进行综述,以期为眼部疾病的发病机制和分子靶点提供指导.
Pathogen infection and non-pathogenic factors can trigger immune responses,leading to eye inflammation.The cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway is a recently discovered inflammatory signaling pathway that recognizes double-stranded DNA as an activation sig-nal to promote the expression of downstream cytokines in inflammatory or autoimmune responses.More and more evidence has shown that the cGAS-STING signaling pathway plays a key role in mediating ocular inflammation and inflammatory dis-eases,including dry eye,keratitis,uveitis,glaucoma,diabetic retinopathy,and age-related macular degeneration.This article reviews the research on the role of the cGAS-STING pathway in eye diseases,in order to provide guidance for the pathogen-esis and molecular targets of eye diseases.
王烽;赖江峰;曹玲英;邵毅
514000 广东省梅州市,梅州市人民医院眼科514000 广东省梅州市,梅州市人民医院眼科514000 广东省梅州市,梅州市人民医院眼科200080 上海市,上海交通大学医学院附属第一人民医院眼科国家眼部疾病临床医学研究中心
医药卫生
环化酸鸟苷-腺苷酸合成酶-干扰素基因刺激因子信号转导通路眼部炎症角膜炎糖尿病视网膜病变年龄相关性黄斑变性葡萄膜炎
cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genessig-nal transduction pathwayocular inflammationkeratitisdiabetic retinopathyage-related macular degenerationuveitis
《眼科新进展》 2026 (2)
154-158,5
国家自然科学基金项目(编号:82160195)
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