前额叶-海马-内侧隔核环路的theta-gamma相位幅值耦合:跨脑区协同与工作记忆调控机制OACHSSCD

Working memory,as the foundation of higher-order cognitive functions,depends on the dynamic coordination within the Prefrontal-Hippocampal-medial Septal neural circuit.Within this circuit,θ-γ phase-amplitude coupling(Theta-gamma phase-amplitude coupling,TG-PAC)serves as a critical mechanism for cross-regional information integration.This article systematically elucidates the central regulatory role of TG-PAC in working memory within the Prefrontal-Hippocampal-medial Septal network.Research has demonstrated that the prefrontal cortex sustains information representations in working memory through persistent neural activity.Its θ rhythm(4～8 Hz)modulates γ rhythm(30～80 Hz)via phase coordination,forming temporal windows essential for cognitive control.As the hub for spatial information processing,the hippocampal supports spatial navigation and the binding of working memory through θ-γ nested coding,where the coupling strength between local γ activity and the θ rhythm could predict memory capacity and behavioral performance.Cross-regional coupling between the prefrontal θ phase and hippocampal gamma amplitude establishes a dynamic interface for cognitive control and memory storage,ensuring the precise execution of working memory tasks.The medial septum,acting as a crucial relay node,regulates the intensity and spatiotemporal characteristics of TG-PAC through its cholinergic,GABAergic,and glutamatergic neurons by modulating hippocampus θ rhythms,thereby influencing working memory efficiency.Notably,abnormalities in TG-PAC are closely associated with cognitive impairments in schizophrenia and Alzheimer's disease,highlighting its clinical value as a potential biomarker and neuromodulation target.This study innovatively integrates the tripartite Prefrontal-Hippocampal-medial Septal circuit coupling,and prospect future research to integrate multimodal imaging,cell-specific regulation,and computational modeling,so as to promote new intervention strategies for cognitive disorders based on neural oscillation coupling.