基于子午流注理论择时隔药灸脐法治疗脾虚湿蕴证溃疡性结肠炎的临床研究OA
Clinical Study on Time-Selected Medicinal-Separated Umbilical Moxibustion in Treatment of Ulcerative Colitis of Spleen Deficiency and Dampness Retention Syndrome Based on Theory of Midnight-Noon Ebb-Flow
目的:探讨基于子午流注理论择时隔药灸脐法治疗脾虚湿蕴证溃疡性结肠炎(UC)的临床疗效及安全性.方法:以2024年10月至2025年7月于江西中医药大学附属医院就诊的符合纳排标准的90例脾虚湿蕴证UC患者为研究对象.通过随机数字表法将其分成A组(美沙拉嗪组)、B组(隔药脐灸组)和C组(隔药脐灸巳时组),每组30例.三组均治疗8周.比较各组临床疗效,治疗前后中医证候积分、改良Mayo评分及炎症因子肿瘤坏死因子-α(TNF-α)和白介素-10(IL-10)水平,以及不良反应发生情况.结果:美沙拉嗪组、隔药脐灸组、隔药脐灸巳时组治疗总有效率分别为86.67%、90.00%和93.33%,依次升高,但差异无统计学意义(P>0.05).中医证候改善方面,证候总积分、肢体困倦、食少纳差评分比较,隔药脐灸巳时组优于隔药脐灸组和美沙拉嗪组(P<0.05);腹部隐痛评分,隔药脐灸巳时组优于美沙拉嗪组(P<0.05),而与隔药脐灸组相比差异无统计学意义(P>0.05).治疗后,美沙拉嗪组、隔药脐灸组、隔药脐灸巳时组改良Mayo评分和血清TNF-α水平依次降低,IL-10水平依次升高,组间比较,隔药脐灸组和隔药脐灸巳时组均优于美沙拉嗪组(P<0.05),但隔药脐灸组与隔药脐灸巳时组差异无统计学意义(P>0.05).三组均未发生严重不良反应,安全性良好.结论:隔药脐灸治疗脾虚湿蕴证UC疗效确切,尤其是基于子午流注理论择时隔药灸脐法在改善肢体困倦和食少纳差方面效果更好,且安全性良好,更具推广价值.
Objective To explore the clinical efficacy and safety of time-selected medicinal-separated umbilical moxibustion in the treatment of ulcerative colitis(UC)of spleen deficiency and dampness retention syndrome based on the theory of midnight-noon ebb-flow.Methods A total of 90 UC patients of spleen defi-ciency and dampness retention syndrome who met the inclusion and exclusion criteria and were treated in the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from October 2024 to July 2025 were selected as the study objects.They were divided into group A(the mesalazine group),group B(the medicinal-separated umbilical moxibustion group)and group C(the medicinal-separated umbilical moxibustion at Si-time group)by random number table method,with 30 cases in each group.All three groups received 8 weeks of treatment.The clinical efficacy,scores of traditional Chinese medicine(TCM)syndrome and modified Mayo score before and after treatment,serum levels of inflammatory factors including tumor necrosis factor-α(TNF-α)and interleukin-10(IL-10),as well as the incidence of adverse reactions were compared among the three groups.Results The total effective rates of group A,group B and group C were 86.67%,90.00%and 93.33%respectively,showing an increasing trend,but the difference was not statistically significant(P>0.05).In terms of improvement of TCM syndromes,the total syndrome score,scores of limb lassitude and poor appetite in group C were superior to those in group B and group A(P<0.05).The score of dull abdomi-nal pain in group C was superior to that in group A(P<0.05),while there was no significant difference com-pared with group B(P>0.05).After treatment,the modified Mayo score and serum level of TNF-α decreased sequentially in group A,group B and group C,while the level of IL-10 increased sequentially.Inter-group comparison showed that group B and group C were superior to group A(P<0.05),but there was no sig-nificant difference between group B and group C(P>0.05).No severe adverse reactions occurred in the three groups,indicating good safety.Conclusion Medicinal-separated umbilical moxibustion has a definite cura-tive effect in the treatment of UC of spleen deficiency and dampness retention syndrome.In particular,time-selected medicinal-separated umbilical moxibustion based on the theory of midnight-noon ebb-flow has a better effect in improving limb lassitude and poor appetite,with good safety and higher promotion value.
王逸;邓永文;张全辉;孙伟康
江西中医药大学(江西 南昌 330006)江西中医药大学附属医院肛肠科(江西 南昌 330006)江西中医药大学附属医院肛肠科(江西 南昌 330006)江西中医药大学(江西 南昌 330006)
溃疡性结肠炎子午流注隔药灸脐脾虚湿蕴证
Ulcerative colitisTheory of midnight-noon ebb-flowMedicinal-separated umbilical moxibus-tionSpleen deficiency and dampness retention syndrome
《中国肛肠病杂志》 2026 (2)
39-43,5
江西省研究生创新专项资金项目(YC2024-S737)
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