血清亲环素A、白细胞介素-6在急性心肌梗死患者介入术后支架内血栓形成中的预测价值OA
Predictive value of serum cyclophilin A and interleukin 6 for stent thrombosis after percutaneous coronary intervention in patients with acute myocardial infarction
目的 探讨血清亲环素A(CyPA)、白细胞介素-6(IL-6)对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后支架内血栓形成的影响及对血栓形成的预测价值.方法 选择2021年1月至2023年6月于湖州市第一人民医院行PCI的122例AMI患者作为研究对象,术后 2 h检测患者血清CyPA、IL-6,并随访 1 年,统计患者PCI后支架内血栓形成情况,运用多因素Logistic回归分析血清CyPA、IL-6 与AMI患者PCI后支架内血栓形成的关系,同时绘制ROC曲线,分析血清CyPA、IL-6 对AMI患者PCI后支架内血栓形成的预测价值.结果 随访 1 年,122 例患者中PCI后发生支架内血栓有 24 例,为发生组,其余 98 例纳入未发生组.发生组与未发生组糖尿病、术前心功能不全占比比较,差异有统计学意义(χ2=4.245、8.421,P<0.05);PCI后2 h及随访时,发生组血清CyPA、IL-6 水平均高于未发生组,差异有统计学意义(t=4.887、16.268、3.868、50.747,P<0.05);Logistic回归分析结果显示,合并糖尿病、术前心功能不全、血清CyPA和IL-6水平高是AMI患者PCI后支架内血栓形成的危险因素(OR=14.906、17.802、1.851、1.196,P<0.05);绘制ROC曲线,结果显示血清CyPA、IL-6 单独预测AMI患者PCI后支架内血栓形成的AUC均>0.7,联合预测的AUC>0.8,联合预测价值更高.结论 血清CyPA、IL-6水平升高是AMI患者PCI后支架内血栓形成的影响因素,临床可将其作为AMI患者PCI后发生支架内血栓形成的预测指标.
Objective To investigate the impact of serum cyclophilin A(CyPA)and interleukin-6(IL-6)on stent thrombosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI)and their predictive value for thrombosis.Methods A total of 122 AMI patients who underwent PCI at the First People's Hospital of Huzhou City from January 2021 to June 2023 were enrolled.Serum levels of CyPA and IL-6 were measured 2 hours post-PCI.All patients were followed up for 1 year to document stent thrombosis events.Multivariate Logistic regression analysis was performed to evaluate the association between serum CyPA,IL-6 levels and stent thrombosis after PCI.Receiver operating characteristic(ROC)curve analysis was conducted to assess the predictive value of CyPA and IL-6 for post-PCI stent thrombosis in AMI patients.Results The patients were followed up for one year.Among the 122 patients,24 cases developed stent thrombosis after PCI and were classified as the occurrence group,while the remaining 98 cases were included in the non-occurrence group.There were statistically significant differences in the proportions of diabetes and preoperative cardiac dysfunction between the occurrence group and the non-occurrence group(χ2=4.245,8.421;P<0.05).The occurrence group demonstrated significantly higher serum CyPA and IL-6 levels both at 2h post-PCI and during follow-up compared to the non-occurrence group,and the differences were statistically significant(t=4.887,16.268,3.868,50.747;P<0.05).Multivariate Logistic regression analysis identified diabetes,preoperative cardiac dysfunction,elevated serum CyPA and IL-6 as risk factors for stent thrombosis after PCI in AMI patients(OR=14.906,17.802,1.851,1.196;P<0.05).The ROC curve analysis revealed that the areas under the curve(AUCs)of serum CyPA and IL-6 predicting stent thrombosis in AMI patients after PCI alone were both greater than 0.7,while the AUC of combined prediction was greater than 0.8,indicating superior predictive value.Conclusion Elevated levels of serum CyPA and IL-6 are risk factors for stent thrombosis in AMI patients after PCI,and can be clinically used as predictive indicators for stent thrombosis in AMI patients after PCI.
施吉
313000 浙江省湖州市第一人民医院心内科
急性心肌梗死经皮冠状动脉介入治疗支架内血栓形成亲环素A白细胞介素-6
Acute myocardial infarctionPercutaneous coronary interventionStent thrombosisCyclophilic AInterleukin-6
《心脑血管病防治》 2026 (1)
42-45,50,5
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