针刺力敏腧穴治疗腹泻型肠易激综合征的临床研究OA

Objective To evaluate the clinical efficacy of acupuncture on force-sensitive acupoints with different sensitization degrees in treatment of diarrhea-predominant irritable bowel syndrome(IBS-D).Methods A total of 108 patients with IBS-D were randomly divided into a high-sensitivity group(36 cases,2 cases dropped out),a low-sensitivity group(36 cases,1 case dropped out)and a waiting group(36 cases,2 cases dropped out).In the high-sensitivity group,5 high-sensitivity(the lowest pain threshold)acupoints were selected in acupuncture treatment,and in the low-sensitivity group,5 low-sensitivity(the highest pain threshold)acupoints were selected.The patients in both groups received 3 times of acupuncture treatment per week,lasting 6 consecutive weeks.The patients in the waiting group did not receive any treatment during the research and the non-investigational standard acupuncture therapy would be provided after follow-up,3 times a week,for 6 consecutive weeks.The scores of IBS severity scale(IBS-SSS)and IBS quality of life scale(IBS-QOL),and fecal traits of Bristol fecal form scale(BSFS)were evaluated before and after treatment,as well as in follow-up.The occurrence of adverse reactions was recorded.Results Compared with those before treatment,the scores of IBS-SSS and IBS-QOL in the waiting group were not significantly different after treatment or in follow-up;the scores of IBS-SSS and IBS-QOL in the high-sensitivity group and the low-sensitivity group were decreased at each time point(P<0.05).When compared with the waiting group,the score of IBS-SSS in either the high-sensitivity group or the low-sensitivity group were reduced,starting from 2 weeks after treatment and till the follow-up(P<0.05).In 4 and 6 weeks of treatment and during follow-up,the score of IBS-SSS in the high-sensitivity group was lower than that in the low-sensitivity group(P<0.05).In comparison with the score in the waiting group,the scores of IBS-QOL were reduced in both the high-sensitivity group and the low-sensitivity group after treatment and in follow-up(P<0.05);and the score in the high-sensitivity group was lower than that of the low-sensitivity group(P<0.05).In the waiting group,there was no statistically significant difference in fecal traits of BSFS after treatment and in follow-up,but the improvements in BSFS were obtained in the high-sensitivity group and the low-sensitivity group(P<0.01).When compared with the waiting group,the improvements in BSFS were presented in the high-sensitivity group and low-sensitivity group after treatment and in follow-up(P<0.01).No significant adverse reactions were observed in all groups.Conclusion Acupuncture at force-sensitive acupoints has a definite curative effect on IBS-D.This therapy is high in safety and satisfactory in long-term effect.In the aspects of the alleviation of the severity of symptoms and the improvement of the quality of life in the patients with IBS-D,acupuncture at force-sensitive acupoints with high sensitivity is more effective than that with low sensitivity.