1992-2021年中国脑出血疾病负担的年龄-时期-队列模型分析OA

Objective To analyze the trends in disease burden of intracerebral hemorrhage(ICH)in China from 1992 to 2021,with a focus on evaluating the effects of age,period,and birth cohorts on ICH incidence and mortality,so as to provide reference for ICH prevention and control.Methods Based on the Global Burden of Disease 2021 database,Joinpoint regression was used to analyze the temporal trends in ICH incidence,mortality,and disability-adjusted life years(DALYs).An age-period-cohort(APC)model was applied to assess the age,period,and cohort effects on the disease burden of ICH in China from 1992 to 2021.Results The 2021 study revealed that the age-standardized incidence rate,age-standardized mortality rate,and age-standardized DALYs rate of ICH in China decreased by 44.48%,48.64%,and 50.09%,respectively,compared with 1992.However,the absolute number of incidence cases,deaths,and DALYs increased.The disease burden was higher in males than in females,and the declines in these indicators were more pronounced in females.APC analysis showed that the incidence and mortality of ICH increased significantly with age,especially in the elderly population.Meanwhile,the late-birth cohort exhibited lower risk of ICH morbidity and mortality than the early-birth cohort.Conclusion The age-standardized rate of ICH disease burden in China shows a declining trend,reflecting the effective interventions in stroke prevention and treatment.However,further interventions targeting high-risk groups,such as elder males,remain critical.