不同中医证型青壮年近视患者视神经纤维层厚度和黄斑区视网膜厚度临床分析OA

Objective:To analyze the differences of retinal nerve fiber layer and macula retinal thickness in young myopic patients with different traditional Chinese medicine(TCM)syndrome types,and to explore the correlation between TCM syndrome types with retinal nerve fiber layer and macula retinal thickness of myopia.Methods:In this study,268 cases(268 eyes)of young myopic patients were classified by TCM syndrome differentiation.The differences of retinal nerve fiber layer thickness and macular retinal thickness between different TCM syndrome types were compared and the related factors were analyzed.Results:①TCM syndrome differentiation:Among 268 myopic patients,66 cases(24.63%)of deficiency of heart Yang,102 cases(38.06%)of deficiency of Qi and blood,100cases(37.31%)of defi-ciency of liver and kidney.There were no statistical significance in gender and age of the three groups of syndrome types(P>0.05);but there were statistically significant differences in diopter and axial length(P<0.001),the diopter showed a decreasing trend,while axial length showed a increasing trend.②Comparison of retinal nerve fiber layer thickness:The difference between the three groups of syndrome types was statistically significant(P<0.05).Except for the temporal area,the retinal nerve fiber layer thickness became thinner(deficiency of heart Yang>deficiency of Qi and blood>deficiency of liver and kidney).③Comparison of macular retinal thickness:In central area,there was no significant difference in the three groups of syndrome types(P>0.05);In intra-macular ring areas and extra-macular ring areas,except for the extra temporal area,the differences of the syndrome types in the three groups were statistical-ly significant(P<0.05),and macular retinal thickness became thinner(deficiency of heart Yang>deficiency of Qi and blood>deficiency of liver and kidney).④Correlation analysis of retinal nerve fiber layer thickness:No correlation with gender(P>0.05),negative correlation with age(P<0.05).Positive correlation with diopter(P<0.05),nega-tive correlation with axial length(P<0.05),except for the temporal area.⑤Correlation analysis of macular retinal thickness:negative correlation with gender(P<0.05);no correlation with age(P>0.05);In fovea:retinal thickness was not correlated with diopter(P>0.05),but was positive correlated with axial length(P<0.05);In other areas:retinal thickness was positive correlated with diopter(P<0.05)and negative correlated with axial length(P<0.05).Conclusion:Deficiency of Qi and blood and deficiency of liver and kidney are the most common syndromes in young myopic patients.The diopter,axial length,retinal nerve fiber layer thickness,macular retinal thickness have some differences among different TCM syndromes.The diopter was higher,the axial length was longer,the thickness of reti-nal nerve fiber layer and macular retinal were thinner in deficiency of liver and kidney patients.The changes of thick-ness of retinal nerve fiber layer and macula are closely related to the diopter and axial length,and partly related to gen-der and age.The findings will provide reference for TCM syndrome differentiation and treatment of young myopic pa-tients.