电针风府、哑门穴治疗偏头痛模型大鼠的作用效果及机制研究OA

Objective:To investigate the efficacy and mechanism of electroacupuncture at Fengfu and Yamen acupoints in treating migraine rats.Methods:The experiment was divided into a normal group(A),model group(B),electroacu-puncture group(C),and electroacupuncture control group(D).The model was established by subcutaneous injection of nitroglycerin.After 7 days of corresponding treatment in each group,behavioral scoring and molecular experiments were conducted.Results:Behavioral scores showed a significant decrease in the number of head scratching and cage climbing behaviors in rats treated with electroacupuncture relative to the model group.The results of both immunohis-tochemistry and immunoprotein blotting experiments showed that migraine rats given electroacupuncture treatment had elevated 5-HT1A expression in the hippocampus(P<0.05),whereas TLR2 and IL-1β expression were downregu-lated(P<0.05).And compared with D,group C was more advantageous in elevating 5-HT1A and down-regulating the expression of TLR2 and IL-1β(P<0.05).Conclusion:Acupuncture points have certain specificity,and electroacupunc-ture stimulation given to acupuncture points can reduce the symptoms of migraine in rats,and the mechanism may be related to the up-regulation of the expression of 5-HT1A,and the down-regulation of the expression of TLR2 and IL-1β.