基于上转换纳米粒子的光触发联合疗法在肿瘤治疗中的应用OA
Application of photo-triggered combination therapy based on upconversion nanoparticle in cancer treatment
光动力疗法(PDT)作为一种新兴的肿瘤治疗手段,近年来受到广泛关注.然而,传统用于激活光敏剂(PS)的紫外光(UV)或可见光(VIS)对生物组织的穿透能力较弱,这在很大程度上限制了PDT的治疗效果.上转换纳米粒子(UCNPs)因具有较强的组织穿透能力,而能够将近红外光(NIR)转化为UV或VIS.将其作为PS的载体,可实现NIR触发的PS激活功能.因此,构建基于UCNPs的PDT体系(UCNP-PDT)为提升治疗效果提供了新的思路.此外,该体系还可通过UCNPs负载其他药物,从而实现多模式的联合治疗.综述了基于UCNPs的PDT体系在联合治疗中的研究进展,进一步探讨光触发药物的释放机制,并对联合治疗体系的生物安全性进行了总结,以期为该体系在临床方面的应用提供参考.
Photodynamic therapy(PDT)has emerged as a promising treatment for tumors and has gained widespread attention in recent years.However,ultraviolet-visible(UV/VIS)light traditionally used to activate photosensitizers has limited tissue penetration,which significantly limits the therapeutic efficacy of PDT.Upconversion nanoparticles(UCNPs)have stronger tissue penetration capabilities and can convert near-infrared(NIR)light into UV/VIS light.When used as carriers for photosensitizers,UCNPs enable NIR-triggered activation of photosensitizers.Consequently,the development of a PDT system based on UCNPs presents a novel approach for enhancing PDT effectiveness.Furthermore,this system can also load other drugs via UCNPs,facilitating multimodal combination therapy.This review summarizes the research progress of UCNP-based PDT systems in combination therapy,explores the mechanisms of photo-triggered drug release,and evaluates the biosafety of these combination therapy systems,providing valuable insights for their clinical application.
王森;聂丽蓉;郭栋;郑佳宇;卢明夏
上海理工大学 健康科学与工程学院,上海 200093上海理工大学 健康科学与工程学院,上海 200093上海理工大学 健康科学与工程学院,上海 200093上海理工大学 健康科学与工程学院,上海 200093上海理工大学 健康科学与工程学院,上海 200093
化学化工
上转换纳米粒子光触发联合治疗光动力生物安全性
UCNPsphoto-triggeredcombination therapyphotodynamicbiosafety
《生物加工过程》 2026 (1)
74-83,99,11
上海市青年科技英才扬帆计划(21FY1431300)
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