基于代谢组学的复合益生菌发酵对黄芪、甘草、刺五加活性组分影响解析OA

Based on the metabolomics platform,the active components of Astragalus,Glycyrrhizaand Acan-thopanax powder fermented by compound probiotics were studied.Results 156 different metabolites were screened before and after fermentation,of which 124 were significantly reduced,mainly flavonoids.The con-tents of 32 substances were significantly increased,mainly amino acids,and their action pathways involved the biosynthesis of flavonoids,amino acids and various plant secondary metabolites,the metabolism of amino acids and sugars,and the signal transduction of plant hormones.Studies have found that complex probiotics can convert most of the flavonoid glycosides in Astragalus,Glycyrrhiza and Acanthopanax into active aglycones by releasing various enzymes,achieving the transformation or decomposition of some triterpenoids,alkaloids,and saccharides,part of triterpenoids,alkaloids and sugars,and pro-moting the accumulation of amino acids.And the synthesis or full release of different types of flavo-noids,alkaloids,organic acids,and vitamin components.The study can provide theoretical reference for the analysis of natural plant of natural plant and probiotic fermentation.