基于临界慢化原理探讨胃"炎-癌转化"中西医防治思路OA
Discussion on the Prevention and Treatment of Gastric"Inflammation-Cancer Transformation"Based on the Principle of Critical Slowing Down in Chinese and Western Medicine
本文将临界慢化原理引入胃"炎-癌转化"这一复杂、非线性的动态演化规律,探究可干预关键节点.从宏观和微观层面,探索胃"炎-癌转化"过程中失稳态的早期识别体系构建思路:基于人工智能技术将宏观的中医四诊辨证及内镜检查与微观的血清分子标志物及微生物检测相结合.从中医整体恒动视角,探讨失稳态阶段有效的中医药干预策略:在邪毒入侵的起始阶段,重在减少外界干扰因素;在胃腑气乱之渐进期,重在增强人体自身恢复力;在胃络形变的后期,重在把握病势以释顽疾,以重塑胃的内环境平衡及自我调节功能.本文以期在胃"炎-癌转化"的关键时期阻断或逆转疾病进程,为中西医防治胃癌前病变提供新思路.
This study introduces the principle of critical slowing down to investigate the complex and non-linear dynamic evolution of the stomach's"inflammation-to-cancer transformation"and to identify key intervention points.It explores the construction of an early identification system for unstable states during this transformation from both macro and micro perspectives.The proposed approach integrates TCM's four diagnostic methods and endoscopic examination at the macro level with serum molecular biomarkers and microbiome testing at the micro level,supported by artificial intelligence technology.From the holistic and dynamic perspective of TCM,it also examines effective intervention strategies at the unstable stage.In the initial stage of noxious invasion,priority is given to minimizing external disruptive factors;in the progressive phase of visceral Qi derangement,the focus shifts to strengthening the body's intrinsic capacity for self-restoration.And in the late stage when the gastric collaterals are structurally altered,the key lies in harnessing the momentum of the disease to dissolve the stubborn affliction,thereby re-establishing the stomach's internal milieu and its self-regulating functions.With the aim of halting or reversing the disease trajectory during the critical window of gastric"inflammation-to-cancer transition",this approach offers a novel perspective for integrated Chinese-Western prevention and treatment of precancerous gastric lesions.
欧阳冀琪;张润顺;王懿;沈垚村;吕文良
中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053||北京中医药大学研究生院 北京 100029中国中医科学院广安门医院 北京 100053||北京中医药大学研究生院 北京 100029中国中医科学院广安门医院 北京 100053
医药卫生
临界慢化炎-癌转化胃癌前病变宏微结合中医防治
Critical slowing downInflammation-cancer transformationGastric precancerous lesionsMacro-micro integrationTCM prevention and treatment
《世界科学技术-中医药现代化》 2026 (1)
86-96,11
国家中医药管理局中央高水平中医医院临床研究和成果转化能力提升项目-传承名老中医药专家学术经验专项(HLCMHPP2023013):岐黄学者吕文良学术思想、临床经验传承研究,负责人:汪九重深圳市卫生健康委员会深圳市医疗卫生三名工程项目资助(SZZYSM202311014):中国中医科学院广安门医院吕文良教授中西医结合肝病诊治专家团队,负责人:吕文良国家中医药管理局中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者支持项目(国中医药人教函[2022]6号),负责人:吕文良.
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